| Amphotericin B-induced severe hypertension in a young patient: case report and review of the literature. | |
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MedLine Citation:
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PMID: 16538979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The description of the association between the use of amphotericin-B (amB) and the development of systemic arterial hypertension was only anecdotal so far. We describe the case of a 19-year-old female patient who had acute lymphoblastic leukemia and developed prolonged neutropenia after reinduction chemotherapy. Candida parapsilosis was isolated from blood cultures, and amB was started. Sustained severe arterial hypertension developed shortly after amB administration and continued for several hours after the infusion. Aldosterone, blood urea nitrogen, and creatinine levels were normal. After clinical improvement, amB was replaced by fluconazole, and blood pressure normalized. Severe hypertension may be an adverse event associated with AmB treatment that requires intensive treatment. |
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Authors:
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Celso Arrais Rodrigues; Mihoko Yamamoto; Adriano de Moraes Arantes; Maria de Lourdes L F Chauffaille; Arnaldo Lopes Colombo; José Orlando Bordin |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Renal failure Volume: 28 ISSN: 0886-022X ISO Abbreviation: Ren Fail Publication Date: 2006 |
Date Detail:
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Created Date: 2006-03-16 Completed Date: 2006-06-19 Revised Date: 2008-05-21 |
Medline Journal Info:
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Nlm Unique ID: 8701128 Medline TA: Ren Fail Country: United States |
Other Details:
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Languages: eng Pagination: 185-7 Citation Subset: IM |
Affiliation:
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Division of Hematology, Department of Medicine, Universidade Federal De São Paulo, São Paulo, Brazil. celsoarrais@uol.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amphotericin B / adverse effects* Antifungal Agents / adverse effects* Fatal Outcome Female Follow-Up Studies Humans Hypertension / chemically induced* Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 1397-89-3/Amphotericin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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