Document Detail

Amphiphilic property of chlorhexidine and its toxicity against Streptococcus mutans GS-5.
MedLine Citation:
PMID:  7869125     Owner:  NLM     Status:  MEDLINE    
The toxicity of chlorhexidine digluconate against Streptococcus mutans GS-5 was comparatively determined by measuring its bactericidal activity, and its inhibitory effect on microbial dehydrogenases was studied by the resazurin reduction method. Both methods indicated that chlorhexidine within the range 0.75-5.00 mg/l was highly toxic to Streptococcus mutans, probably due to inhibition of dehydrogenase activity, and the extent of toxicity was closely associated with concentration. In an attempt to better understand the relationship between the amphiphilic nature of chlorhexidine and its toxicity against Streptococcus mutans, the effect of solvent polarity on dehydrogenase inhibition was investigated. A decrease in solvent polarity, induced by inclusion of 5% acetone in the reaction mixture, did not enhance the toxicity of chlorhexidine. This implies that the antimicrobial action of chlorhexidine is mainly attributable to its hydrophilicity, and that the nature of the lipophilic groups is only of secondary importance.
S Koontongkaew; S Jitpukdeebodintra
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of Nihon University School of Dentistry     Volume:  36     ISSN:  0029-0432     ISO Abbreviation:  J Nihon Univ Sch Dent     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-03-30     Completed Date:  1995-03-30     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7509209     Medline TA:  J Nihon Univ Sch Dent     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  235-40     Citation Subset:  D; IM    
Department of Oral Biology and Occlusion, Faculty of Dentistry, Prince Songkla University, Thailand.
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MeSH Terms
Acetone / chemistry,  pharmacology
Chemistry, Physical
Chlorhexidine / analogs & derivatives,  chemistry*,  pharmacology,  toxicity*
Colony Count, Microbial
Indicators and Reagents / chemistry
Oxazines / chemistry
Oxidoreductases / antagonists & inhibitors,  drug effects
Physicochemical Phenomena
Streptococcus mutans / classification,  drug effects*,  isolation & purification
Reg. No./Substance:
0/Indicators and Reagents; 0/Oxazines; 0/Xanthenes; 55-56-1/Chlorhexidine; 550-82-3/resazurin; 67-64-1/Acetone; EC 1.-/Oxidoreductases; MOR84MUD8E/chlorhexidine gluconate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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