Document Detail

Amphiphilic drug persuaded collapse of polyvinylpyrrolidone and poly(ethylene glycol) chains: a dynamic light scattering study.
MedLine Citation:
PMID:  19889521     Owner:  NLM     Status:  MEDLINE    
Light scattering has proved to be useful in characterizing colloidal systems. We have studied the interaction between an amphiphilic drug, amitriptyline hydrochloride (AMT), and neutral polymers, polyvinylpyrrolidone (PVP) and poly(ethylene glycol) (PEG), using the dynamic light scattering (DLS) technique. AMT was found to interact with PVP more strongly than PEG. A large decrease of the size of aggregates upon increase of AMT concentration indicates a successive collapse of the polymer conformation. The partial negatively charged oxygen atoms, present in the amide group of PVP, were believed to be responsible for the collapse while interacting with the cationic head group of AMT. Presence of NaBr in the solution enhanced the effect markedly and made the AMT-PVP aggregates more compact. The PEG aggregates also showed a similar behavior, although less pronounced than the PVP. The results obtained in the present investigations may be helpful to design the drug delivery systems for the antidepressant drugs as the higher concentration of these drugs is harmful for the human body. Likewise, as the results have shown that on increasing the temperature there is a decrease in the extent of interaction; this may be helpful for the controlled release formulations.
Mohd Sajid Ali; Goutam Ghosh; Kabir-ud-Din
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-12
Journal Detail:
Title:  Colloids and surfaces. B, Biointerfaces     Volume:  75     ISSN:  1873-4367     ISO Abbreviation:  Colloids Surf B Biointerfaces     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9315133     Medline TA:  Colloids Surf B Biointerfaces     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  590-4     Citation Subset:  IM    
Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India.
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MeSH Terms
Amitriptyline / chemistry*
Bromides / chemistry
Particle Size
Polyethylene Glycols / chemistry*
Povidone / chemistry*
Scattering, Radiation*
Sodium Compounds / chemistry
Reg. No./Substance:
0/Bromides; 0/Polyethylene Glycols; 0/Sodium Compounds; 0/Solutions; 50-48-6/Amitriptyline; 7647-15-6/sodium bromide; 9003-39-8/Povidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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