Document Detail


Amphetamine- and morphine-induced feeding: evidence for involvement of reward mechanisms.
MedLine Citation:
PMID:  2325945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study examined the possibility that the increased feeding found following central and peripheral administrations of low doses of d-amphetamine (AMP) and morphine (MOR) may involve central reward mechanisms. In order to examine this possibility, the effects of these drugs on food selection and intake of foods that varied in palatability and nutritive content were determined. In addition, the importance of the nucleus accumbens (ACB), a critical structure for AMP and MOR reward, in these effects was determined. Results indicated that MOR increased the intake of preferred food regardless of nutritive content. In contrast, AMP was most effective at increasing the intake of preferred foods which contained carbohydrates. These effects were observed following systematic or intra-ACB administration of low doses of MOR and AMP. Together these findings implicate reward mechanisms in the expression of MOR- and AMP-induced feeding. It is further suggested that the feeding effects of MOR and AMP can be differentiated in paradigms where animals have a choice of several foods which may vary in palatability and/or nutritive content. The relevance of the present findings for our understanding of which elements of food and feeding behavior are coupled with ACB reward signals is also discussed.
Authors:
K R Evans; F J Vaccarino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  14     ISSN:  0149-7634     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  1990  
Date Detail:
Created Date:  1990-05-21     Completed Date:  1990-05-21     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amphetamines / pharmacology*
Animals
Feeding Behavior / drug effects*
Male
Morphine / pharmacology*
Nucleus Accumbens / drug effects,  physiology*
Nutrition Disorders / physiopathology
Rats
Rats, Inbred Strains
Reward*
Septal Nuclei / physiology*
Chemical
Reg. No./Substance:
0/Amphetamines; 76I7G6D29C/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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