| Amphetamine-modified acoustic startle responding and prepulse inhibition in adult and adolescent alcohol-preferring and -nonpreferring rats. | |
| | |
MedLine Citation:
|
PMID: 12759124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Selective breeding has been used to develop the alcohol-preferring (P) and -nonpreferring (NP) rats, with the P rat having lower CNS levels of dopamine (DA) and reduced DA innervation in the nucleus accumbens compared with the NP rat. The acoustic startle response (ASR) and prepulse inhibition (PPI) of the ASR are experimental behaviors altered by DA agonists. We examined whether functional differences in amphetamine (AMPH)-modified ASR and PPI exist between P and NP rats. AMPH [0.0 (saline), 1.0, 2.0, or 4.0 mg/kg] was injected 15 min prior to placement into a startle apparatus. After a 5-min habituation period, rats were given approximately twelve 95-, 105-, or 115-dB white-noise burst (ASR) and PPI trials. As adults, P rats were sensitive to AMPH potentiation of the ASR to a greater extent than NP rats. During adolescence, P and NP rats had similar levels of AMPH-potentiated ASR. As adults, NP rats displayed potentiated, rather than disrupted, PPI at the 1.0-mg/kg dose, whereas P rats displayed the expected disrupted PPI at the 4.0-mg/kg dose. As adolescents, NP rats did not display significant differences in PPI after AMPH, whereas P rats displayed dose-dependent disruption of PPI, which was significant at the 4.0-mg/kg dose. The limited effect of AMPH on increasing the ASR and the presence of AMPH-potentiated PPI at the lowest dose in the adult NP rat suggests reduced functioning of the interactions between DA circuits and the neurocircuitry mediating the ASR and PPI, compared with P rats. However, the neurocircuitry mediating PPI does not appear to be fully developed in the adolescent NP rat. The present findings also indicate that lower levels of DA content and immunoreactive fibers in the P rat may not reflect reduced DA neuronal activity, because the P rat displayed AMPH-potentiated ASR, and, at the highest dose, AMPH disruption of PPI during both adulthood and adolescence. |
| | |
Authors:
|
R L Bell; Z A Rodd; C C Hsu; L Lumeng; J M Murphy; W J McBride |
Related Documents
:
|
3715204 - The effect of chronic ethanol ingestion on the inotropic effect of nifedipine. 12730804 - The impairment of hepatocytes and sinusoidal endothelial cells during cold preservation... 15630194 - Hepatoprotective activity of tocha, the stems and leaves of ampelopsis grossedentata, a... 2539814 - Diethylthiocarbamic acid methyl ester. a potent inhibitor of aldehyde dehydrogenase fou... 8895844 - Free radical scavenging activity of the japanese herbal medicine toki-shakuyaku-san (tj... 20049984 - Effect of polyamine-deficient chow on trypanosoma brucei brucei infection in rats. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Pharmacology, biochemistry, and behavior Volume: 75 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2003 Apr |
Date Detail:
|
Created Date: 2003-05-21 Completed Date: 2004-01-07 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
|
Languages: eng Pagination: 163-71 Citation Subset: IM |
Affiliation:
|
Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA. ribell@iupui.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acoustic Stimulation Aging / psychology* Alcohol Drinking / genetics*, psychology* Amphetamine / pharmacology* Animals Central Nervous System Stimulants / pharmacology* Dopamine / physiology Dopamine Uptake Inhibitors / pharmacology* Dose-Response Relationship, Drug Female Rats Startle Reaction / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
|
AA 07462/AA/NIAAA NIH HHS; AA 07611/AA/NIAAA NIH HHS; AA 10256/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Central Nervous System Stimulants; 0/Dopamine Uptake Inhibitors; 300-62-9/Amphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memo...
Next Document: Dimenhydrinate produces a conditioned place preference in rats.