| Amphetamine-induced dopamine release in the rat striatum: an in vivo microdialysis study. | |
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MedLine Citation:
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PMID: 2447237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of a number of biochemical and pharmacological manipulations on amphetamine (AMPH)-induced alterations in dopamine (DA) release and metabolism were examined in the rat striatum using the in vivo brain microdialysis method. Basal striatal dialysate concentrations were: DA, 7 nM; dihydroxyphenylacetic acid (DOPAC), 850 nM; homovanillic acid (HVA), 500 nM; 5-hydroxyindoleacetic acid (5-HIAA), 300 nM; and 3-methoxytyramine (3-MT), 3 nM. Intraperitoneal injection of AMPH (4 mg/kg) induced a substantial increase in DA efflux, which attained its maximum response 20-40 min after drug injection. On the other hand, DOPAC and HVA efflux declined following AMPH. The DA response, but not those of DOPAC and HVA, was dose dependent within the range of AMPH tested (2-16 mg/kg). High doses of AMPH (greater than 8 mg/kg) also decreased 5-HIAA and increased 3-MT efflux. Depletion of vesicular stores of DA using reserpine did not affect significantly AMPH-induced dopamine efflux. In contrast, prior inhibition of catecholamine synthesis, using alpha-methyl-p-tyrosine, proved to be an effective inhibitor of AMPH-evoked DA release (less than 35% of control). Moreover, the DA releasing action of AMPH was facilitated in pargyline-pretreated animals (220% of control). These data suggest that AMPH releases preferentially a newly synthesised pool of DA. Nomifensine, a DA uptake inhibitor, was an effective inhibitor of AMPH-induced DA efflux (18% of control). On the other hand, this action of AMPH was facilitated by veratrine and ouabain (200-210% of control). These results suggest that the membrane DA carrier may be involved in the actions of AMPH on DA efflux. |
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Authors:
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S P Butcher; I S Fairbrother; J S Kelly; G W Arbuthnott |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurochemistry Volume: 50 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-02-23 Completed Date: 1988-02-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 346-55 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Edinburgh, Scotland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Amphetamine / pharmacology* Animals Corpus Striatum / drug effects, metabolism* Dialysis Dopamine / analogs & derivatives, metabolism* Dose-Response Relationship, Drug Homovanillic Acid / metabolism Hydroxyindoleacetic Acid / metabolism Male Methyltyrosines / pharmacology Nomifensine / pharmacology Ouabain / pharmacology Pargyline / pharmacology Rats Rats, Inbred Strains Reserpine / pharmacology Veratrine / pharmacology alpha-Methyltyrosine |
| Chemical | |
Reg. No./Substance:
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0/Methyltyrosines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 24526-64-5/Nomifensine; 300-62-9/Amphetamine; 306-08-1/Homovanillic Acid; 50-55-5/Reserpine; 54-16-0/Hydroxyindoleacetic Acid; 554-52-9/3-methoxytyramine; 555-57-7/Pargyline; 62-59-9/Veratrine; 630-60-4/Ouabain; 658-48-0/alpha-Methyltyrosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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