Document Detail

Amphetamine-induced changes in immunoreactive NPY in rat brain, pineal gland and plasma.
MedLine Citation:
PMID:  3841736     Owner:  NLM     Status:  MEDLINE    
Acute injection of d-amphetamine (10 mg/kg), administered to rats 60 minutes prior to sacrifice, induced a doubling of immunoreactive NPY (NPY-IR) in pineal gland. No changes, however, could be detected in levels of NPY-IR in grossly dissected or microdissected regions of rat brain, nor were changes evident in plasma level concentrations of NPY-IR following acute amphetamine pretreatment. When amphetamine was injected twice daily for six days and once more 60 minutes prior to sacrifice, levels of NPY-IR were decreased in caudate putamen and the paraventricular and dorsomedial nuclei of the hypothalamus, while concentrations of NPY-IR were increased in medial preoptic nucleus, pineal gland, and plasma. These data indicate that levels of NPY-IR are susceptible to manipulation by amphetamine, where the extent and direction of change (increase or decrease) depends on both the frequency of drug administration and the nature of the sampled tissue. Based on the effects of amphetamine on central and peripheral norepinephrine and epinephrine disposition observed in other studies, the data also suggest that NPY-IR and catecholamine dispositions are not directly correlated and may be inversely related in some tissue.
R E Tessel; D A DiMaggio; T L O'Donohue
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  6     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1985 Nov-Dec
Date Detail:
Created Date:  1986-05-23     Completed Date:  1986-05-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1219-24     Citation Subset:  IM    
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MeSH Terms
Brain / drug effects,  metabolism*
Dextroamphetamine / pharmacology*
Nerve Tissue Proteins / blood,  metabolism*
Neuropeptide Y
Pineal Gland / drug effects,  metabolism*
Radioimmunoassay / methods
Rats, Inbred Strains
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Neuropeptide Y; 51-64-9/Dextroamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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