| Amphetamine and 2-phenylethylamine in post-mortem Parkinsonian brain after (-)deprenyl administration. | |
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MedLine Citation:
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PMID: 745019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deprenyl is an inhibitor of monoamine oxidase type B, the enzyme responsible for 2-phenylethylamine oxidation, and is used in conjunction with L-Dopa therapy in Parkinson's disease. Post-mortem studies in human brain tissue have shown that after (-)deprenyl administration to parkinsonian patients amphetamine is present in concentrations up to 56 ng/g. It also could be shown that phenylethylamine concentrations are substantially increased in such patients. Phenylethylamine and amphetamine have been investigated using a gas chromatographic technique. |
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Authors:
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G P Reynolds; P Riederer; M Sandler; K Jellinger; D Seemann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neural transmission Volume: 43 ISSN: 0300-9564 ISO Abbreviation: J. Neural Transm. Publication Date: 1978 |
Date Detail:
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Created Date: 1979-05-23 Completed Date: 1979-05-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0337042 Medline TA: J Neural Transm Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 271-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphetamines
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metabolism* Brain / metabolism* Humans Parkinson Disease / drug therapy*, metabolism Phenethylamines / metabolism*, therapeutic use* Selegiline / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Amphetamines; 0/Phenethylamines; 14611-51-9/Selegiline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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