Document Detail

Amphetamine and 2-phenylethylamine in post-mortem Parkinsonian brain after (-)deprenyl administration.
MedLine Citation:
PMID:  745019     Owner:  NLM     Status:  MEDLINE    
Deprenyl is an inhibitor of monoamine oxidase type B, the enzyme responsible for 2-phenylethylamine oxidation, and is used in conjunction with L-Dopa therapy in Parkinson's disease. Post-mortem studies in human brain tissue have shown that after (-)deprenyl administration to parkinsonian patients amphetamine is present in concentrations up to 56 ng/g. It also could be shown that phenylethylamine concentrations are substantially increased in such patients. Phenylethylamine and amphetamine have been investigated using a gas chromatographic technique.
G P Reynolds; P Riederer; M Sandler; K Jellinger; D Seemann
Related Documents :
7909929 - Inhibitory effect of neuropeptide y (npy) on the in vitro activity of tyrosine hydroxyl...
7865179 - Monoamine oxidase inhibition by the mao-a inhibitors brofaromine and clorgyline in heal...
12939789 - Anti-dipsotropic isoflavones: the potential therapeutic agents for alcohol dependence.
8627609 - Selective inhibitors of monoamine oxidase. 3. structure-activity relationship of tricyc...
3992869 - The seasonal prevalence of inhibited development of haemonchus contortus in sheep in se...
10467129 - Interactions of (-)-ilimaquinone with methylation enzymes: implications for vesicular-m...
16657799 - An examination of methods used to assay potato tuber invertase and its naturally occurr...
1429699 - Feedback inhibition of phosphatidate phosphatase from spinach chloroplast envelope memb...
1015959 - Acetate metabolism in rhodopseudomonas gelatinosa and several other rhodospirillaceae.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neural transmission     Volume:  43     ISSN:  -     ISO Abbreviation:  J. Neural Transm.     Publication Date:  1978  
Date Detail:
Created Date:  1979-05-23     Completed Date:  1979-05-23     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0337042     Medline TA:  J Neural Transm     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  271-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amphetamines / metabolism*
Brain / metabolism*
Parkinson Disease / drug therapy*,  metabolism
Phenethylamines / metabolism*,  therapeutic use*
Selegiline / therapeutic use*
Reg. No./Substance:
0/Amphetamines; 0/Phenethylamines; 14611-51-9/Selegiline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Overview of present day treatment of Parkinson's disease.
Next Document:  Cellular junctions in human oesophageal epithelium.