Document Detail


Amphetamine and 2-phenylethylamine in post-mortem Parkinsonian brain after (-)deprenyl administration.
MedLine Citation:
PMID:  745019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deprenyl is an inhibitor of monoamine oxidase type B, the enzyme responsible for 2-phenylethylamine oxidation, and is used in conjunction with L-Dopa therapy in Parkinson's disease. Post-mortem studies in human brain tissue have shown that after (-)deprenyl administration to parkinsonian patients amphetamine is present in concentrations up to 56 ng/g. It also could be shown that phenylethylamine concentrations are substantially increased in such patients. Phenylethylamine and amphetamine have been investigated using a gas chromatographic technique.
Authors:
G P Reynolds; P Riederer; M Sandler; K Jellinger; D Seemann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neural transmission     Volume:  43     ISSN:  -     ISO Abbreviation:  J. Neural Transm.     Publication Date:  1978  
Date Detail:
Created Date:  1979-05-23     Completed Date:  1979-05-23     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0337042     Medline TA:  J Neural Transm     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  271-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amphetamines / metabolism*
Brain / metabolism*
Humans
Parkinson Disease / drug therapy*,  metabolism
Phenethylamines / metabolism*,  therapeutic use*
Selegiline / therapeutic use*
Chemical
Reg. No./Substance:
0/Amphetamines; 0/Phenethylamines; 14611-51-9/Selegiline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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