Document Detail

Amoxycillin, amoxycillin-clavulanic acid and metronidazole in the treatment of clue cell-positive discharge. A comparative clinical and laboratory study.
MedLine Citation:
PMID:  3429374     Owner:  NLM     Status:  MEDLINE    
In an open study, 30 women with clue cell-positive discharge (CCPD) were treated for seven days with either amoxycillin, amoxycillin-clavulanic acid or metronidazole (ten in each group). Patients were monitored on days 2, 4, 9 and 15. Clinical and microscopical parameters were used to assess treatment efficacy. Gas-liquid chromatography of vaginal secretions was also performed. The succinate-lactate ratio had good correlation with the clinical findings. All patients treated with metronidazole were cured by day 4, suggesting that a three-day course is as effective as the standard seven-day regimen. Treatment with amoxycillin-clavulanic acid was less effective resulting in the cure of seven patients by day 15. Amoxycillin established normal secretions in only four patients. Gastro-intestinal complaints, although common in patients treated with amoxycillin-clavulanic acid, were generally mild. We consider amoxycillin-clavulanic acid a possible alternative in the treatment of CCPD.
W I van der Meijden; P Piot; S M Loriaux; E Stolz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  20     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-03-07     Completed Date:  1988-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  735-42     Citation Subset:  IM    
Department of Dermatology and Venereology, University Hospital Dijkzigt, Rotterdam, The Netherlands.
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MeSH Terms
Amoxicillin / therapeutic use*
Bacterial Infections / drug therapy
Clavulanic Acid
Clavulanic Acids / therapeutic use*
Drug Therapy, Combination
Metronidazole / therapeutic use*
Microbial Sensitivity Tests
Vaginitis / drug therapy*,  microbiology
Reg. No./Substance:
0/Clavulanic Acids; 26787-78-0/Amoxicillin; 443-48-1/Metronidazole; 58001-44-8/Clavulanic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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