Document Detail

Amoxicillin therapy for Chlamydia trachomatis in pregnancy.
MedLine Citation:
PMID:  2325959     Owner:  NLM     Status:  MEDLINE    
For treating Chlamydia trachomatis cervical infection in pregnancy, the Centers for Disease Control guidelines recommend either erythromycin base or erythromycin ethylsuccinate. There is no alternate therapy. Because of compliance problems with erythromycin regimens due to gastrointestinal side effects, such an alternative is needed. For this reason, we compared, in an open trial, the efficacy and patient compliance of amoxicillin (500 mg three times a day for 7 days) with those of erythromycin base (500 mg four times a day for 7 days) in treating C trachomatis cervical infections during pregnancy. In the amoxicillin group, 63 of 64 women (98.4%) had negative cervical cultures after treatment, compared with 55 of 58 women (94.8%) treated with erythromycin base. Vertical transmission to the infants was assessed by culture and/or persistent or rising immunoglobulin G antichlamydial antibody. In the amoxicillin group, 37 of 39 infants (94.9%) had no evidence of chlamydial infection, compared with 32 of 36 infants (88.8%) in the erythromycin group. These differences were not significant. The frequency of side effects was higher with erythromycin base than with amoxicillin (15 versus 8%), although not significantly so. However, the frequency of stopping medication because of side effects was significantly higher with erythromycin base than with amoxicillin (13 versus 2%; P less than .006). These results suggest that amoxicillin may be an acceptable alternative treatment for chlamydial infections in pregnancy.
W R Crombleholme; J Schachter; M Grossman; D V Landers; R L Sweet
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  75     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-05-18     Completed Date:  1990-05-18     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  752-6     Citation Subset:  AIM; IM    
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco.
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MeSH Terms
Amoxicillin / adverse effects,  therapeutic use*
Chlamydia Infections / drug therapy*
Chlamydia trachomatis
Erythromycin / adverse effects,  therapeutic use
Infant, Newborn
Patient Compliance
Pregnancy Complications, Infectious / drug therapy*
Uterine Cervical Diseases / drug therapy*
Grant Support
Reg. No./Substance:
114-07-8/Erythromycin; 26787-78-0/Amoxicillin
Comment In:
Obstet Gynecol. 1990 Nov;76(5 Pt 1):896-7   [PMID:  2216248 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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