Document Detail


Amount but not pattern of protective sensory stimulation alters recovery after permanent middle cerebral artery occlusion.
MedLine Citation:
PMID:  21317269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Using a rodent model of ischemia (permanent middle cerebral artery occlusion), our laboratory previously demonstrated that 4.27 minutes of patterned single-whisker stimulation delivered over 120 minutes can fully protect from impending damage when initiated within 2 hours of permanent middle cerebral artery occlusion ("early"). When initiated 3 hours postpermanent middle cerebral artery occlusion ("late"), stimulation resulted in irreversible damage. Here we investigate the effect of altering pattern, distribution, or amount of stimulation in this model.
METHODS: We assessed the cortex using functional imaging and histological analysis with altered stimulation treatment protocols. In 2 groups of animals we administered the same number of whisker deflections but in a random rather than patterned fashion distributed either over 120 minutes or condensed into 10 minutes postpermanent middle cerebral artery occlusion. We also tested increased (full-whisker array versus single-whisker) stimulation.
RESULTS: Early random whisker stimulation (condensed or dispersed) resulted in protection equivalent to early patterned stimulation. Early full-whisker array patterned stimulation also resulted in complete protection but promoted faster recovery. Late full-whisker array patterned stimulation, however, resulted in loss of evoked function and infarct volumes larger than those sustained by single-whisker counterparts.
CONCLUSIONS: When induced early on after ischemic insult, stimulus-evoked cortical activity, irrespective of the parameters of peripheral stimulation that induced it, seems to be the important variable for neuroprotection.
Authors:
Melissa F Davis; Christopher C Lay; Cynthia H Chen-Bee; Ron D Frostig
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-02-11
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  42     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-21     Completed Date:  2011-04-19     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  792-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / physiology
Infarction, Middle Cerebral Artery / physiopathology*,  prevention & control*
Male
Physical Stimulation / methods
Random Allocation
Rats
Rats, Sprague-Dawley
Recovery of Function / physiology*
Time Factors
Touch / physiology*
Vibrissae / physiology*
Grant Support
ID/Acronym/Agency:
NS-066001/NS/NINDS NIH HHS; NS-55832/NS/NINDS NIH HHS; R01 NS066001/NS/NINDS NIH HHS; R01 NS066001-02/NS/NINDS NIH HHS
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