| Amount but not pattern of protective sensory stimulation alters recovery after permanent middle cerebral artery occlusion. | |
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MedLine Citation:
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PMID: 21317269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Using a rodent model of ischemia (permanent middle cerebral artery occlusion), our laboratory previously demonstrated that 4.27 minutes of patterned single-whisker stimulation delivered over 120 minutes can fully protect from impending damage when initiated within 2 hours of permanent middle cerebral artery occlusion ("early"). When initiated 3 hours postpermanent middle cerebral artery occlusion ("late"), stimulation resulted in irreversible damage. Here we investigate the effect of altering pattern, distribution, or amount of stimulation in this model. METHODS: We assessed the cortex using functional imaging and histological analysis with altered stimulation treatment protocols. In 2 groups of animals we administered the same number of whisker deflections but in a random rather than patterned fashion distributed either over 120 minutes or condensed into 10 minutes postpermanent middle cerebral artery occlusion. We also tested increased (full-whisker array versus single-whisker) stimulation. RESULTS: Early random whisker stimulation (condensed or dispersed) resulted in protection equivalent to early patterned stimulation. Early full-whisker array patterned stimulation also resulted in complete protection but promoted faster recovery. Late full-whisker array patterned stimulation, however, resulted in loss of evoked function and infarct volumes larger than those sustained by single-whisker counterparts. CONCLUSIONS: When induced early on after ischemic insult, stimulus-evoked cortical activity, irrespective of the parameters of peripheral stimulation that induced it, seems to be the important variable for neuroprotection. |
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Authors:
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Melissa F Davis; Christopher C Lay; Cynthia H Chen-Bee; Ron D Frostig |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-11 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 42 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-21 Completed Date: 2011-04-19 Revised Date: 2012-09-19 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 792-8 Citation Subset: IM |
Affiliation:
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University of California-Irvine, 2205 McGaugh Hall, Ring Road, Department of Neurobiology & Behavior, UCI, Irvine CA 92697, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / physiology Infarction, Middle Cerebral Artery / physiopathology*, prevention & control* Male Physical Stimulation / methods Random Allocation Rats Rats, Sprague-Dawley Recovery of Function / physiology* Time Factors Touch / physiology* Vibrissae / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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NS-066001/NS/NINDS NIH HHS; NS-55832/NS/NINDS NIH HHS; R01 NS066001-02/NS/NINDS NIH HHS |
| Comments/Corrections | |
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