Document Detail


Amorimia exotropica poisoning as a presumptive cause of myocardial fibrosis in cattle.
MedLine Citation:
PMID:  22362807     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The current study reports the investigation on the cause of sudden deaths associated with cardiac fibrosis in cattle in northern Rio Grande do Sul, Brazil. The exclusion of known causes of bovine cardiac fibrosis as well as the absence of the plants in that region whose consumption has already been linked to the disorder motivated this investigation. The condition, which was attributed to the consumption of Amorimia exotropica, affected draft oxen, most of which died suddenly without showing any clinical signs during usual management or work. Globular hearts with white foci at their cut surfaces were the main gross findings, which corresponded microscopically from multifocal to coalescent areas of myocardial fibrosis. To confirm the condition, A. exotropica from the ranches where cattle died from the disease was dosed to rabbits, which showed similar lesions to those seen in dead cattle after receiving 10 doses of 3.6 g/kg at 4-day intervals. Electron microscopy on rabbit tissues revealed severe tumefaction of the cardiomyocytes associated with mitochondrial swelling, displacement, and rupture of the mitochondrial crests, and of the bundles of myofibrils, apart from large glycogen deposits within the sarcoplasm. It is suggested that mitochondrial changes triggered alterations that lead to cardiac fibrosis and that all of these changes were induced by A. exotropica cardiotoxicity.
Authors:
Mauro Pereira Soares; Saulo Petinatti Pavarini; Maria de Lourdes Adrien; Pedro de Souza Quevedo; Ana Lucia Schild; Paulo Vargas Peixoto; Cláudio Estêvão Farias da Cruz; David Driemeier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc     Volume:  23     ISSN:  1943-4936     ISO Abbreviation:  J. Vet. Diagn. Invest.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2012-02-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011490     Medline TA:  J Vet Diagn Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1226-9     Citation Subset:  IM    
Affiliation:
1David Driemeier, Departamento de Patologia Clínica Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves, no. 9090, 91540-000 Porto Alegre, RS, Brazil. davetpat@ufrgs.br.
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