| Amniotic membrane transplantation as a new therapy for the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis. | |
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MedLine Citation:
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PMID: 19699503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stevens-Johnson syndrome and its more severe variant, toxic epidermal necrolysis, have relatively low overall incidence; however, this disease presents with high morbidity and mortality. The majority of patients develop ocular inflammation and ulceration at the acute stage. Due to the hidden nature of these ocular lesions and the concentration of effort toward life-threatening issues, current acute management has not devised a strategy to preclude blinding cicatricial complications. This review summarizes recent literature data, showing how sight-threatening corneal complications can progressively develop from cicatricial pathologies of lid margin, tarsus, and fornix at the chronic stage. It illustrates how such pathologies can be prevented with the early intervention of cryopreserved amniotic membrane transplantation to suppress inflammation and promote epithelial healing at the acute stage. Significant dry eye problems and photophobia can also be avoided with this intervention. This new therapeutic strategy can avert the catastrophic ophthalmic sequelae of this rare but devastating disease. |
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Authors:
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Elizabeth Shay; Ahmad Kheirkhah; Lingyi Liang; Hossam Sheha; Darren G Gregory; Scheffer C G Tseng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-08-21 |
Journal Detail:
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Title: Survey of ophthalmology Volume: 54 ISSN: 1879-3304 ISO Abbreviation: Surv Ophthalmol Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-10-12 Completed Date: 2009-11-23 Revised Date: 2011-04-21 |
Medline Journal Info:
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Nlm Unique ID: 0404551 Medline TA: Surv Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 686-96 Citation Subset: IM |
Affiliation:
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TissueTech Inc., Miami, Florida, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Amnion / transplantation* Child Child, Preschool Conjunctival Diseases / etiology, surgery* Corneal Diseases / etiology, surgery* Epidermal Necrolysis, Toxic / etiology, surgery* Female Humans Male Stevens-Johnson Syndrome / etiology, surgery* Tissue Preservation Wound Healing |
| Grant Support | |
ID/Acronym/Agency:
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R44 EY014768-03/EY/NEI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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