Document Detail

Amniotic fluid zinc and pregnancy outcome.
MedLine Citation:
PMID:  8163029     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine for an association between amniotic fluid zinc and pregnancy outcome. DESIGN: A prospective study. SETTING: Southmead Hospital, Bristol, UK. SUBJECTS: 191 amniotic fluid samples from 11 centers in the Southwest of England, obtained at 16-20 weeks gestation. METHOD: Samples of amniotic fluid (AF) sent for prenatal diagnosis were collected from the laboratory and analysed for zinc level. Data were then collected at a later date concerning pregnancy outcome. OUTCOME MEASURE: Antenatal complications as well as events in labour, and in particular birth weight and congenital malformations. RESULTS: 182 cases with complete data showed a mean AF zinc level (+/- S.E.) of 1.39 (+/- 0.11). There was no relation between AF zinc and antepartum haemorrhage, pregnancy-induced hypertension, post-partum haemorrhage or time and mode of delivery. Neither was there an association with birth weight. As there were no cases with major malformations, particularly of the central nervous system, possible association could not be ascertained. CONCLUSION: The study failed to demonstrate any association between AF zinc and abnormal pregnancy outcome. A modified prospective study is suggested to explore this further.
K Mahomed; D Grant; D K James
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  52     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-05-23     Completed Date:  1994-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  157-61     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University of Zimbabwe, Harare.
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MeSH Terms
Amniotic Fluid / chemistry*
Birth Weight
Congenital Abnormalities / etiology
Pregnancy Outcome
Prospective Studies
Zinc / analysis*
Reg. No./Substance:

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