Document Detail


Amniotic fluid steroid levels and fetal adrenal weight in congenital adrenal hyperplasia.
MedLine Citation:
PMID:  3502335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentration of 17-OH-progesterone was determined in second trimester amniotic fluid collected from 58 pregnancies at risk for fetal 21-hydroxylase deficiency. The prediction was incorrect in 1 male nonsalt-loser who had an increased plasma 17-OH-progesterone concentration at 3 months of age. All 11 infants predicted to be affected were salt-losers. The adrenals from 2 affected fetuses available for study were significantly enlarged in comparison with adrenal size in 84 normal fetuses from 15 to 26 weeks' gestation. Amniotic fluid steroid analysis reliably predicts the fetus with 21-hydroxylase deficiency most at risk in early infancy. There is no evidence from this study to indicate that ACTH is not the main trophic factor for fetal adrenal growth and steroidogenesis.
Authors:
I A Hughes; J Dyas; K M Laurence
Related Documents :
12646725 - Changes in 5alpha-pregnane steroids and neurosteroidogenic enzyme expression in the per...
17537545 - Ethnic differences in adrenocorticotropic hormone, cortisol and corticotropin-releasing...
11153525 - Fetal hypothalamus-pituitary-adrenal axis on the road to parturition.
10738925 - The prenatal pituitary gland--hidden and forgotten.
5354835 - Severe haemolytic anaemia in pregnancy in nigerians treated with prednisolone.
2049475 - Determination of digoxin in the blood of pregnant women, fetuses and neonates before an...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone research     Volume:  28     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1987  
Date Detail:
Created Date:  1988-05-27     Completed Date:  1988-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  20-4     Citation Subset:  IM    
Affiliation:
Department of Child Health, University of Wales College of Medicine, Cardiff, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
17-alpha-Hydroxyprogesterone
Adrenal Glands / embryology*
Adrenal Hyperplasia, Congenital / diagnosis*,  metabolism,  pathology
Amniotic Fluid / analysis*
Female
Gestational Age
Humans
Hydroxyprogesterones / analysis*
Male
Organ Size
Pregnancy
Prenatal Diagnosis / methods*
Chemical
Reg. No./Substance:
0/Hydroxyprogesterones; 68-96-2/17-alpha-Hydroxyprogesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prevalence and incidence trends of non-insulin-dependent diabetes mellitus (NIDDM) in the population...
Next Document:  Veiled accessory cells deduced from monocytes.