Document Detail

Amniotic fluid steroid levels and fetal adrenal weight in congenital adrenal hyperplasia.
MedLine Citation:
PMID:  3502335     Owner:  NLM     Status:  MEDLINE    
The concentration of 17-OH-progesterone was determined in second trimester amniotic fluid collected from 58 pregnancies at risk for fetal 21-hydroxylase deficiency. The prediction was incorrect in 1 male nonsalt-loser who had an increased plasma 17-OH-progesterone concentration at 3 months of age. All 11 infants predicted to be affected were salt-losers. The adrenals from 2 affected fetuses available for study were significantly enlarged in comparison with adrenal size in 84 normal fetuses from 15 to 26 weeks' gestation. Amniotic fluid steroid analysis reliably predicts the fetus with 21-hydroxylase deficiency most at risk in early infancy. There is no evidence from this study to indicate that ACTH is not the main trophic factor for fetal adrenal growth and steroidogenesis.
I A Hughes; J Dyas; K M Laurence
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone research     Volume:  28     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1987  
Date Detail:
Created Date:  1988-05-27     Completed Date:  1988-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  20-4     Citation Subset:  IM    
Department of Child Health, University of Wales College of Medicine, Cardiff, UK.
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MeSH Terms
Adrenal Glands / embryology*
Adrenal Hyperplasia, Congenital / diagnosis*,  metabolism,  pathology
Amniotic Fluid / analysis*
Gestational Age
Hydroxyprogesterones / analysis*
Organ Size
Prenatal Diagnosis / methods*
Reg. No./Substance:
0/Hydroxyprogesterones; 68-96-2/17-alpha-Hydroxyprogesterone

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