Document Detail

Amniotic fluid phospholipid profile in multiple pregnancy and the effect of zygosity.
MedLine Citation:
PMID:  6639896     Owner:  NLM     Status:  MEDLINE    
Because respiratory distress syndrome (RDS) may occur in one twin but not the other it may be misleading to assess fetal lung maturity using amniotic fluid from only one sac. We compared the amniotic fluid lecithin/sphingomyelin (L/S), phosphatidyl glycerol/sphingomyelin (PG/S) and phosphatidyl inositol/sphingomyelin (PI/S) ratios between co-twins and co-triplets in 32 sets of twins and three set of triplets. In the twin pregnancies we found a weak correlation for L/S ratio but a much improved one for PG/S and PI/S. The concordance between sacs for all three ratios was better in monozygotic than in dizygotic twins. The efficacy of amniotic fluid PG in the determination of fetal lung maturity was demonstrated and the discrepancies between the sacs was much less for PG than for the L/S ratios. Employing the L/S ratio combined with the presence or absence of PG should reduce false results to a minimum.
H G Dobbie; M J Whittle; A I Wilson; C R Whitfield
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  90     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1001-6     Citation Subset:  AIM; IM    
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MeSH Terms
Amniotic Fluid / analysis*
Fetal Organ Maturity
Infant, Newborn
Lung / embryology
Phosphatidylcholines / analysis
Phosphatidylglycerols / analysis
Phosphatidylinositols / analysis
Phospholipids / analysis*
Pregnancy, Multiple*
Prenatal Diagnosis
Respiratory Distress Syndrome, Newborn / diagnosis
Sphingomyelins / analysis
Twins, Dizygotic
Twins, Monozygotic
Reg. No./Substance:
0/Phosphatidylcholines; 0/Phosphatidylglycerols; 0/Phosphatidylinositols; 0/Phospholipids; 0/Sphingomyelins

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