Document Detail

Amniotic fluid phospholipid analysis in the fetus with congenital diaphragmatic hernia.
MedLine Citation:
PMID:  7965499     Owner:  NLM     Status:  MEDLINE    
The substantial morbidity and mortality of congenital diaphragmatic hernia (CDH) is attributed to the pulmonary hypoplasia caused by the presence of abdominal viscera in the chest during intrauterine life. Recent experimental studies suggest that surfactant deficiency may also contribute to CDH pathophysiology. Clinically, the amniocentesis-derived lecithin to sphingomyelin (L/S) ratio and phosphatidylglycerol (PG) data are used to assess fetal lung maturity. We have performed amniotic fluid phospholipid analyses at 33 to 38 weeks' gestation in 18 fetuses with prenatally diagnosed CDH to assess fetal lung maturity, plan optimal timing for delivery, and selectively employ prenatal glucocorticoid or postnatal surfactant therapy. Compared with published control values from uncomplicated pregnancies, there was no difference in the L/S ratio or PG in the CDH fetus. Based on amniotic fluid phospholipid data, the human CDH fetus is not surfactant-deficient.
K M Sullivan; S Hawgood; A W Flake; M R Harrison; N S Adzick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  29     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-12-15     Completed Date:  1994-12-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1020-3; discussion 1023-4     Citation Subset:  IM    
Fetal Treatment Center, University of California, San Francisco 94143-0570.
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MeSH Terms
Amniotic Fluid / chemistry*
Fetal Diseases / metabolism*
Fetal Organ Maturity
Hernia, Diaphragmatic / congenital*,  metabolism*
Infant, Newborn
Lung / embryology
Phosphatidylcholines / analysis
Phospholipids / analysis*
Sphingomyelins / analysis
Reg. No./Substance:
0/Phosphatidylcholines; 0/Phospholipids; 0/Sphingomyelins

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