| Amniotic fluid phospholipid analysis in the fetus with congenital diaphragmatic hernia. | |
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MedLine Citation:
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PMID: 7965499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The substantial morbidity and mortality of congenital diaphragmatic hernia (CDH) is attributed to the pulmonary hypoplasia caused by the presence of abdominal viscera in the chest during intrauterine life. Recent experimental studies suggest that surfactant deficiency may also contribute to CDH pathophysiology. Clinically, the amniocentesis-derived lecithin to sphingomyelin (L/S) ratio and phosphatidylglycerol (PG) data are used to assess fetal lung maturity. We have performed amniotic fluid phospholipid analyses at 33 to 38 weeks' gestation in 18 fetuses with prenatally diagnosed CDH to assess fetal lung maturity, plan optimal timing for delivery, and selectively employ prenatal glucocorticoid or postnatal surfactant therapy. Compared with published control values from uncomplicated pregnancies, there was no difference in the L/S ratio or PG in the CDH fetus. Based on amniotic fluid phospholipid data, the human CDH fetus is not surfactant-deficient. |
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Authors:
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K M Sullivan; S Hawgood; A W Flake; M R Harrison; N S Adzick |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 29 ISSN: 0022-3468 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1994-12-15 Completed Date: 1994-12-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1020-3; discussion 1023-4 Citation Subset: IM |
Affiliation:
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Fetal Treatment Center, University of California, San Francisco 94143-0570. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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chemistry* Fetal Diseases / metabolism* Fetal Organ Maturity Hernia, Diaphragmatic / congenital*, metabolism* Humans Infant, Newborn Lung / embryology Phosphatidylcholines / analysis Phospholipids / analysis* Sphingomyelins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylcholines; 0/Phospholipids; 0/Sphingomyelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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