Document Detail

Amniotic fluid phosphatidylinositol and phosphatidylglycerol. II. Diabetic and preeclamptic pregnancies.
MedLine Citation:
PMID:  532564     Owner:  NLM     Status:  MEDLINE    
139 samples of amniotic fluid from diabetic women collected during 34-39 weeks of pregnancy showed higher levels of lecithin, phosphatidylinositol (PI) and phosphatidylglycerol (PG) indicating an accelerated surfactant synthesis as compared to that observed in normal pregnancies (13). In ten infants with respiratory distress syndrome (RDS) delivered from diabetic mothers the lecithin/sphingomyelin (L/S), PI/S and PG/S ratios were generally low. Only four samples showed definitely immature L/S ratios, whereas the amniotic fluid content of PG in all samples was unmeasurable or low. In 56 samples of amniotic fluid collected during the third trimester from preeclamptic pregnancies PI/S and PG/S ratios after 36-37 weeks were comparable with those of normal pregnancies. In 11 neonates with subsequent RDS the L/S ratios were immature, and PG was critically low or lacking in the majority of the samples. No convincing association between the PI content and development of RDS could be observed in any of the groups.
J Skjaeraasen; S Stray-Pedersen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  58     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1979  
Date Detail:
Created Date:  1980-04-17     Completed Date:  1980-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  433-8     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / analysis*
Infant, Newborn
Lipids / analysis
Phosphatidylcholines / analysis
Phosphatidylglycerols / analysis*
Phosphatidylinositols / analysis*
Phospholipids / analysis
Phosphorus / analysis
Pre-Eclampsia / metabolism*
Pregnancy in Diabetics / metabolism*
Respiratory Distress Syndrome, Newborn / etiology
Sphingomyelins / analysis
Reg. No./Substance:
0/Lipids; 0/Phosphatidylcholines; 0/Phosphatidylglycerols; 0/Phosphatidylinositols; 0/Phospholipids; 0/Sphingomyelins; 7723-14-0/Phosphorus

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