Document Detail

Amniotic fluid phosphatidylglycerol: a predictor of fetal lung maturity using conventional one-dimensional thin-layer chromatography.
MedLine Citation:
PMID:  6623138     Owner:  NLM     Status:  MEDLINE    
We present a retrospective comparative analysis of 209 amniotic fluid samples and the neonatal outcome. The presence of phosphatidylglycerol in 159 transabdominal amniotic fluid samples and the associated lung status indicated a 98% prediction rate for absence of respiratory distress syndrome with 1.8% false-positive results corrected to 0%. Twenty-nine vaginal pool samples were 72% predictive of outcome with false-positive results corrected to 14%. These cases were mild, and if a phosphatidylglycerol level of greater than 3% is used to indicate lung maturity, the corrected false-positive rate is 0%. False-negative results are also corrected and discussed. We believe that predicting neonatal respiratory distress syndrome by phosphatidylglycerol determination, using readily available conventional one-dimensional thin-layer chromatography, is clinically reliable and can aid in determining the maturity of the lung regardless of site of fluid collection.
J R Semmer; T R Traylor; E B Linton; P C Painter; M Meighan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  76     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1257-60     Citation Subset:  AIM; IM    
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MeSH Terms
Amniotic Fluid / analysis*
Chromatography, Thin Layer
Fetal Distress / diagnosis
Fetal Membranes, Premature Rupture / diagnosis
Fetal Organ Maturity
Lung / embryology*
Phosphatidylglycerols / analysis*
Prenatal Diagnosis
Reg. No./Substance:

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