Document Detail

Amniotic fluid odd-chain fatty acids are increased in propionic acidaemia.
MedLine Citation:
PMID:  8938066     Owner:  NLM     Status:  MEDLINE    
Odd-chain (C15 and C17) fatty acids have been reported to accumulate in tissues and body fluids of patients with propionic and methylmalonic acidaemia. We investigated the occurrence of these substances in amniotic fluid samples. The odd-chain fatty acid levels (expressed as the percentage of total C12-C20 fatty acids) in eight control samples ranged from 3.7 to 12.5 per cent. Three samples from affected propionic acidaemia pregnancies had values of 15.3-22.9 per cent; one methylmalonic acidaemia sample had a normal level of 9.3 per cent. These results supply further evidence of the prenatal accumulation of odd-chain fatty acids in propionic acidaemia.
M Coker; M Duran; J B De Klerk; W J Kleijer; C Jakobs; J G Huijmans
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  16     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-27     Completed Date:  1997-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  941-4     Citation Subset:  IM    
Erasmus University, Department of Clinical Genetics, Rotterdam, The Netherlands.
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MeSH Terms
Amino Acid Metabolism, Inborn Errors / diagnosis*
Amniotic Fluid / chemistry*
Fatty Acids / analysis*
Gestational Age
Prenatal Diagnosis*
Propionic Acids / blood*
Reg. No./Substance:
0/Fatty Acids; 0/Propionic Acids

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