Document Detail


Amniotic fluid neutrophil elastase and lactate dehydrogenase: association with histologic chorioamnionitis.
MedLine Citation:
PMID:  16752257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chorioamnionitis (CAM) is considered to be one of the main causes of preterm labor and has been associated with an adverse perinatal outcome in preterm infants. The diagnosis of acute histologic CAM requires delivery and examination of the placenta. Although numbers of markers have been reported to predict histologic CAM before birth, it is unknown whether the levels of neutrophil elastase and lactate dehydrogenase (LDH) in amniotic fluid are associated with histologic CAM. METHODS: Sixty women at gestational age of 16-35 weeks underwent transabdominal amniocentesis within 48 hr before delivery. Amniotic fluid was analyzed for white blood cell count, glucose level, LDH level, and neutrophil elastase level. The levels of neutrophil elastase were measured by latex immunoassay. Following delivery, tissue samples were obtained from umbilical cord, chorionic plate, and placental membranes. Histologic CAM was diagnosed based on Blanc's criteria. RESULTS: Receiver-operator characteristic curve analysis showed that the amniotic fluid neutrophil elastase had the best screening efficiency in predicting histologic CAM. Using amniotic fluid cut-off levels of 0.15 microg/ml for neutrophil elastase and 250 IU/l for LDH, the sensitivity, specificity, and positive and negative predictive values for predicting histologic CAM were 88.9% versus 84.1%, 73.3% versus 66.7%, 90.9% versus 88.1%, and 68.8% versus 58.8%, respectively. CONCLUSION: Amniotic neutrophil elastase and LDH are useful markers in predicting histologic CAM.
Authors:
Kumiko Kidokoro; Madoka Furuhashi; Naohiko Kuno; Kaoru Ishikawa
Related Documents :
2505247 - Non-ketotic hyperglycinaemia: glycine/serine ratio in amniotic fluid--an unreliable met...
8222277 - Fetal intestinal and renal origins of trehalase activity in human amniotic fluid.
11234987 - Fetal death associated with asymptomatic intrauterine candida albicans infection and a ...
8238167 - Interleukin-6 levels in amniotic fluid in normal and abnormal pregnancies: preeclampsia...
18946097 - Placental volumes measured by 3-dimensional ultrasonography in normal pregnancies from ...
23235007 - Total and unbound darunavir (drv) pharmacokinetics (pk) in hiv-1-infected pregnant women.
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  85     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2006  
Date Detail:
Created Date:  2006-06-05     Completed Date:  2006-07-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  669-74     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amniocentesis
Amniotic Fluid / enzymology*
Biological Markers / analysis
C-Reactive Protein / analysis
Chorioamnionitis / diagnosis*,  enzymology
Female
Fetal Membranes, Premature Rupture
Gestational Age
Glucose / analysis
Humans
Infant
L-Lactate Dehydrogenase / analysis*
Leukocyte Count
Leukocyte Elastase / analysis*
Logistic Models
Pregnancy
ROC Curve
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Biological Markers; 50-99-7/Glucose; 9007-41-4/C-Reactive Protein; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 3.4.21.37/Leukocyte Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pregnancy risk increases from 41 weeks of gestation.
Next Document:  The effect of environmental tobacco smoke during pregnancy on birth weight.