Document Detail

Amniotic fluid neutrophil elastase and lactate dehydrogenase: association with histologic chorioamnionitis.
MedLine Citation:
PMID:  16752257     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chorioamnionitis (CAM) is considered to be one of the main causes of preterm labor and has been associated with an adverse perinatal outcome in preterm infants. The diagnosis of acute histologic CAM requires delivery and examination of the placenta. Although numbers of markers have been reported to predict histologic CAM before birth, it is unknown whether the levels of neutrophil elastase and lactate dehydrogenase (LDH) in amniotic fluid are associated with histologic CAM. METHODS: Sixty women at gestational age of 16-35 weeks underwent transabdominal amniocentesis within 48 hr before delivery. Amniotic fluid was analyzed for white blood cell count, glucose level, LDH level, and neutrophil elastase level. The levels of neutrophil elastase were measured by latex immunoassay. Following delivery, tissue samples were obtained from umbilical cord, chorionic plate, and placental membranes. Histologic CAM was diagnosed based on Blanc's criteria. RESULTS: Receiver-operator characteristic curve analysis showed that the amniotic fluid neutrophil elastase had the best screening efficiency in predicting histologic CAM. Using amniotic fluid cut-off levels of 0.15 microg/ml for neutrophil elastase and 250 IU/l for LDH, the sensitivity, specificity, and positive and negative predictive values for predicting histologic CAM were 88.9% versus 84.1%, 73.3% versus 66.7%, 90.9% versus 88.1%, and 68.8% versus 58.8%, respectively. CONCLUSION: Amniotic neutrophil elastase and LDH are useful markers in predicting histologic CAM.
Kumiko Kidokoro; Madoka Furuhashi; Naohiko Kuno; Kaoru Ishikawa
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  85     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2006  
Date Detail:
Created Date:  2006-06-05     Completed Date:  2006-07-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  669-74     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
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MeSH Terms
Amniotic Fluid / enzymology*
Biological Markers / analysis
C-Reactive Protein / analysis
Chorioamnionitis / diagnosis*,  enzymology
Fetal Membranes, Premature Rupture
Gestational Age
Glucose / analysis
L-Lactate Dehydrogenase / analysis*
Leukocyte Count
Leukocyte Elastase / analysis*
Logistic Models
ROC Curve
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; 50-99-7/Glucose; 9007-41-4/C-Reactive Protein; EC Dehydrogenase; EC Elastase

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