Document Detail

Amniotic fluid myeloperoxidase in pregnancies complicated by preterm prelabor rupture of membranes.
MedLine Citation:
PMID:  23039254     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine amniotic fluid myeloperoxidase concentration in women with preterm prelabor rupture of the membranes with microbial invasion of the amniotic cavity and histological chorioamnionitis.
METHODS: One hundred eighty-one women with singleton pregnancies with a gestational age between 24+0 and 36+6 weeks were included in this study. Amniocenteses were performed, and myeloperoxidase concentration in the amniotic fluid was determined using ELISA.
RESULT: Women with microbial invasion of the amniotic cavity had higher median myeloperoxidase concentration than women without this condition (149.2 ng/mL vs. 54.6 ng/mL; p = 0.0006). Women with the presence of histological chorioamnionitis had higher median myeloperoxidase concentration than women without histological chorioamnionitis (103.7 ng/mL vs. 50.0 ng/mL; p = 0.0001). The presence of both microbial invasion of the amniotic cavity and histological chorioamnionitis was associated with higher median myeloperoxidase concentration (456.0 ng/mL vs. 52.9 ng/mL; p < 0.0001). The results remained significant after adjusting for gestational age.
CONCLUSIONS: Increased amniotic fluid myeloperoxidase in microbial invasion of the amniotic cavity and histological chorioamnionitis confirm a role of myeloperoxidase in preterm prelabor rupture of the membranes pathophysiology.
Marian Kacerovsky; Vojtech Tambor; Marie Vajrychová; Juraj Lenco; Helena Hornychova; Ivana Musilova; Ramkumar Menon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-31
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  26     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-19     Completed Date:  2013-08-05     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  463-8     Citation Subset:  IM    
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MeSH Terms
Amnion / microbiology
Amniotic Fluid / enzymology*
Chorioamnionitis / microbiology,  pathology
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Fetal Membranes, Premature Rupture / enzymology*
Gestational Age
Infant, Newborn
Peroxidase / analysis*
Pregnancy Outcome
Premature Birth / enzymology
Retrospective Studies
Sepsis / enzymology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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