Document Detail

Amniotic fluid lamellar body counts for the determination of fetal lung maturity: an update.
MedLine Citation:
PMID:  15843267     Owner:  NLM     Status:  MEDLINE    
AIM: To reassess the cut-off value for lamellar body counts (LBs) for fetal lung maturity (FLM) over a 10-year study period. PATIENTS AND METHODS: 178 pregnancies were selected under strict inclusion criteria and delivered within 48 h from amniocentesis. FLM was determined by amniotic fluid LBs in centrifuged samples (300 x g for 10 min) in a commercially available Coulter Counter. Cases beyond 37 weeks were excluded. RESULTS: Mean gestational age was 33.5+/-3.0 weeks at amniocentesis and 33.7+/-3.0 weeks at birth. After reassessing the best compromise between sensitivity and specificity for all cases using the receiver operating characteristic (ROC) procedure, an FLM cut-off value of < or = 22,000/microL was obtained. Diagnostic accuracy (and confidence interval, CI) was: sensitivity, 73% (60.0-83.6%); specificity, 81.7% (CI 73.6-88.1%); positive predictive value, 66.2%; and negative predictive value, 86.0%. CONCLUSION: No significant change in FLM cut-off for LBs was found when comparing the value from this study and the results of our earlier report presented in 1996 (< or = 22,000 vs. < or = 20,000/microL), although the new value may be more accurate, since it is based on neonatal outcome with the exclusion of cases in which the diagnosis of FLM is seldom warranted, i.e., > 37 weeks' gestational age.
Juan J Piazze; Luca Maranghi; Albana Cerekja; Paolo Meloni; Stefano Gioia; Luisa Fumian; Ermelando V Cosmi; Maurizio M Anceschi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  33     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2005  
Date Detail:
Created Date:  2005-04-21     Completed Date:  2005-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  156-60     Citation Subset:  IM    
Institute of Gynecology, Perinatology and Child Health, University La Sapienza, Rome, Italy.
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MeSH Terms
Amniotic Fluid / chemistry*
Fetal Organ Maturity / physiology*
Gestational Age
Infant, Newborn
Lung / embryology*
Phospholipids / analysis
Prenatal Diagnosis / methods
Respiratory Distress Syndrome, Newborn / diagnosis,  prevention & control
Reg. No./Substance:

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