| Amniotic fluid lamellar body counts for the determination of fetal lung maturity: an update. | |
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MedLine Citation:
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PMID: 15843267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To reassess the cut-off value for lamellar body counts (LBs) for fetal lung maturity (FLM) over a 10-year study period. PATIENTS AND METHODS: 178 pregnancies were selected under strict inclusion criteria and delivered within 48 h from amniocentesis. FLM was determined by amniotic fluid LBs in centrifuged samples (300 x g for 10 min) in a commercially available Coulter Counter. Cases beyond 37 weeks were excluded. RESULTS: Mean gestational age was 33.5+/-3.0 weeks at amniocentesis and 33.7+/-3.0 weeks at birth. After reassessing the best compromise between sensitivity and specificity for all cases using the receiver operating characteristic (ROC) procedure, an FLM cut-off value of < or = 22,000/microL was obtained. Diagnostic accuracy (and confidence interval, CI) was: sensitivity, 73% (60.0-83.6%); specificity, 81.7% (CI 73.6-88.1%); positive predictive value, 66.2%; and negative predictive value, 86.0%. CONCLUSION: No significant change in FLM cut-off for LBs was found when comparing the value from this study and the results of our earlier report presented in 1996 (< or = 22,000 vs. < or = 20,000/microL), although the new value may be more accurate, since it is based on neonatal outcome with the exclusion of cases in which the diagnosis of FLM is seldom warranted, i.e., > 37 weeks' gestational age. |
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Authors:
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Juan J Piazze; Luca Maranghi; Albana Cerekja; Paolo Meloni; Stefano Gioia; Luisa Fumian; Ermelando V Cosmi; Maurizio M Anceschi |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 33 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 2005 |
Date Detail:
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Created Date: 2005-04-21 Completed Date: 2005-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 156-60 Citation Subset: IM |
Affiliation:
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Institute of Gynecology, Perinatology and Child Health, University La Sapienza, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniocentesis Amniotic Fluid / chemistry* Female Fetal Organ Maturity / physiology* Gestational Age Humans Infant, Newborn Lung / embryology* Phospholipids / analysis Pregnancy Prenatal Diagnosis / methods Respiratory Distress Syndrome, Newborn / diagnosis, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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