Document Detail


Amniotic fluid lamellar body counts for the determination of fetal lung maturity: an update.
MedLine Citation:
PMID:  15843267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To reassess the cut-off value for lamellar body counts (LBs) for fetal lung maturity (FLM) over a 10-year study period. PATIENTS AND METHODS: 178 pregnancies were selected under strict inclusion criteria and delivered within 48 h from amniocentesis. FLM was determined by amniotic fluid LBs in centrifuged samples (300 x g for 10 min) in a commercially available Coulter Counter. Cases beyond 37 weeks were excluded. RESULTS: Mean gestational age was 33.5+/-3.0 weeks at amniocentesis and 33.7+/-3.0 weeks at birth. After reassessing the best compromise between sensitivity and specificity for all cases using the receiver operating characteristic (ROC) procedure, an FLM cut-off value of < or = 22,000/microL was obtained. Diagnostic accuracy (and confidence interval, CI) was: sensitivity, 73% (60.0-83.6%); specificity, 81.7% (CI 73.6-88.1%); positive predictive value, 66.2%; and negative predictive value, 86.0%. CONCLUSION: No significant change in FLM cut-off for LBs was found when comparing the value from this study and the results of our earlier report presented in 1996 (< or = 22,000 vs. < or = 20,000/microL), although the new value may be more accurate, since it is based on neonatal outcome with the exclusion of cases in which the diagnosis of FLM is seldom warranted, i.e., > 37 weeks' gestational age.
Authors:
Juan J Piazze; Luca Maranghi; Albana Cerekja; Paolo Meloni; Stefano Gioia; Luisa Fumian; Ermelando V Cosmi; Maurizio M Anceschi
Related Documents :
16888627 - Nud1p, the yeast homolog of centriolin, regulates spindle pole body inheritance in meio...
8532247 - Accelerated fetal lung maturity profiles and maternal cocaine exposure.
14990407 - Neonatal respiratory distress syndrome as a function of gestational age and an assay fo...
21396217 - Standardised second-line treatment of multidrug-resistant tuberculosis during pregnancy.
20666067 - Trends in the obstetric features and management of twin pregnancies.
6846437 - The nature of structural defects associated with velamentous and marginal insertion of ...
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  33     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2005  
Date Detail:
Created Date:  2005-04-21     Completed Date:  2005-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  156-60     Citation Subset:  IM    
Affiliation:
Institute of Gynecology, Perinatology and Child Health, University La Sapienza, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amniocentesis
Amniotic Fluid / chemistry*
Female
Fetal Organ Maturity / physiology*
Gestational Age
Humans
Infant, Newborn
Lung / embryology*
Phospholipids / analysis
Pregnancy
Prenatal Diagnosis / methods
Respiratory Distress Syndrome, Newborn / diagnosis,  prevention & control
Chemical
Reg. No./Substance:
0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The association of birthweight with maternal and cord serum and amniotic fluid growth hormone and in...
Next Document:  Comparison of clinical criteria with echocardiographic findings in diagnosing PDA in preterm infants...