Document Detail

Amniotic fluid interleukin-6 increase is an indicator of spontaneous preterm birth in white but not black Americans.
MedLine Citation:
PMID:  18166313     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study examined the differences in the inflammatory cytokine interleukin (IL)-6 and the immunoinhibitory cytokine IL-10 in the amniotic fluid of black and white women in spontaneous preterm birth. METHODS: In this study, 321 amniotic fluids from cases (preterm birth 36 or fewer weeks' gestation) and controls (normal term delivery longer than 37 weeks' gestation) were collected (147 cases [49 blacks and 98 whites] and 174 controls [85 blacks and 89 whites]) at the time of active labor. IL-6 and IL-10 concentrations were measured by immunoassays. Using normal-term delivery as controls, logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs) for preterm birth. RESULTS: A significant difference in IL-6 concentration was observed in white cases (cases: 3773 pg/mL; controls: 1682 pg/mL; P = .0003), compared with controls, but not in blacks (cases: 2042 pg/mL; controls: 2366 pg/mL; P = .6). In a combined multivariable analysis, when the highest and the lowest quartiles of IL-6 were compared in whites, the ORs (95% CI) for preterm birth across quartiles were 1.74 (0.62-4.88), 1.09 (0.39-3.02), and 5.68 (2.15-15.0). No such association was found in blacks. IL-10 concentration was not different between cases and controls in either race. CONCLUSIONS: Race-specific associations exist between IL-6 but not IL-10 concentration and preterm birth. Elevated IL-6 concentrations are associated with preterm birth in whites but not blacks.
Ramkumar Menon; M Constanza Camargo; Poul Thorsen; Salvatore J Lombardi; Stephen J Fortunato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  198     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-01     Completed Date:  2008-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77.e1-7     Citation Subset:  AIM; IM    
Perinatal Research Center of the Women's Health Research and Education Foundation, Women's Hospital at the Centennial Medical Center, Nashville, TN 37203, USA.
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MeSH Terms
African Americans / statistics & numerical data*
Amniotic Fluid / metabolism*
Biological Markers / analysis
Case-Control Studies
Delivery, Obstetric / methods
European Continental Ancestry Group / statistics & numerical data*
Gestational Age
Infant, Newborn
Interleukin-10 / analysis
Interleukin-6 / analysis*
Linear Models
Odds Ratio
Premature Birth / ethnology*
Reference Values
Risk Assessment
Sensitivity and Specificity
Term Birth / ethnology
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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