| Amniotic fluid interleukin-1 in spontaneous labor at term. | |
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MedLine Citation:
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PMID: 2325034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The regulatory signals responsible for the increased biosynthesis of prostaglandins during parturition have not been established. Interleukin-1 (IL-1) is capable of stimulating prostaglandin production by intrauterine tissues and is an inflammation mediator. It has been postulated as a signal for the onset of labor in the setting of intrauterine infection. A study was designed to determine if spontaneous labor at term was associated with changes in IL-1 activity in amniotic fluid. Such fluid was retrieved from 41 women in labor and from 39 women who were not in labor at term. Immunodetectable IL-1 beta was present in 22 of the 41 women in labor but in only 8 of the 39 women without labor. IL-1-like bioactivity was not different between the two groups at a dilution of 1:4, but at dilutions of 1:12, 1:36 and 1:108, amniotic fluid from women in labor had significantly higher bioactivity than that from women not in labor. A significant correlation was found between the bioassay and immunoassay results. Our data show that inhibitors of IL-1 bioactivity are present in amniotic fluid and suggest that in a subset of laboring women at term, an inflammatory reaction may play a role in triggering the onset of parturition. |
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Authors:
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R Romero; S T Parvizi; E Oyarzun; M Mazor; Y K Wu; C Avila; A P Athanassiadis; M D Mitchell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 35 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 1990 Mar |
Date Detail:
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Created Date: 1990-05-16 Completed Date: 1990-05-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 235-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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analysis* Female Humans Interleukin-1 / metabolism* Labor, Obstetric / metabolism* Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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