Document Detail

Amniotic fluid endothelin levels and the incidence of premature rupture of membranes.
MedLine Citation:
PMID:  16434046     Owner:  NLM     Status:  MEDLINE    
Objective. The purpose of this prospective study was to record Endothelin 1 (ET1) concentrations in the second trimester amniotic fluid and in women who develop premature rupture of membranes (PROM), preterm premature rupture of the membranes (PPROM) and in women with uneventful pregnancies. Method. Amniotic fluid was retrieved by amniocentesis from 125 women in the second trimester of pregnancy. The levels of Endothelin were measured by a sensitive and specific radioimmunoassay. Results. From the 125 women included in the study 20 developed PROM and preterm PROM (13 PPROM and 7 PROM). The ET1 concentration was significantly higher (P<0.001) in PROM and PPROM than in normal pregnancy (96.4 vs. 43 pg/ml). The sub-analysis of the two rupture of membranes groups found that the concentration of ET1 was higher in the PPROM than in PROM (118 vs. 72 pg/ml). Conclusion. The amniotic fluid concentration of ET1 is elevated by the second trimester in women who later develop preterm PROM or term PROM.
L Margarit; A N Griffiths; V Tsapanos; S Tsakas; G Decavalas
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Publication Detail:
Type:  Journal Article     Date:  2006-01-24
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  93     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-06     Completed Date:  2006-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  18-21     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University Hospital of Patras, Patras, Greece.
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MeSH Terms
Amniotic Fluid / chemistry*
Body Mass Index
Case-Control Studies
Endothelins / analysis*
Fetal Membranes, Premature Rupture / etiology*,  metabolism*
Gestational Age
Pregnancy Trimester, Second
Prospective Studies
Reg. No./Substance:

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