Document Detail

Amniotic fluid composition responds to changes in maternal dietary carbohydrate and is related to metabolic status in term fetal rats.
MedLine Citation:
PMID:  1732479     Owner:  NLM     Status:  MEDLINE    
The objective of this study was twofold: 1) to determine whether amniotic fluid composition responded to differences in the level or source (glucose vs. fructose) of maternal dietary carbohydrate, and 2) to establish whether any dietary-induced changes in amniotic fluid composition correlated with maternal or fetal metabolic status at term. Pregnant rat dams were fed graded levels (0, 4, 12 and 60%) of glucose or fructose in a triglyceride-based diet (Experiment 1) or isoenergetic low carbohydrate diets having 4% glucose equivalents as glucose, fructose, or lipid-glycerol (Experiment 2) throughout pregnancy. Amniotic fluid and maternal and fetal samples were collected at term (d21). Results demonstrated a significant increase in amniotic fluid glucose and a significant decrease in amniotic fluid uric acid as the level of carbohydrate increased in the maternal diet. Pearson correlation coefficients showed amniotic fluid glucose to be positively associated with maternal and fetal liver glycogen and fetal weight; amniotic fluid uric acid and urea nitrogen were negatively correlated with these same measures. Regression analysis indicated that amniotic fluid glucose was predictive of fetal body weight and fetal liver glycogen at term. The findings show that amniotic fluid can be modified by maternal diet and suggest that composition of amniotic fluid might be used as an accessible nutritional indicator of carbohydrate status in the developing fetus.
K G Koski; M A Fergusson
Related Documents :
11132589 - Novel technique for assessing amniotic fluid volume: use of a three-dimensional bladder...
6307049 - Amniotic fluid beta-endorphin and beta-lipotropin concentrations during the second and ...
9380309 - Amniotic fluid volume in normal singleton pregnancies.
18366489 - Prediction of small for gestational age newborns using ultrasound estimated and actual ...
12765319 - The effects of asthma on pregnancy and perinatal outcomes.
11547649 - Decreased amniotic fluid index in low-risk pregnancy.
7757809 - Evidence that a non-steroidal factor from ovine placenta inhibits aromatase activity of...
23840989 - Pregnancy with concomitant chorioangioma and placental mesenchymal dysplasia: a rare pl...
2087099 - Fetal and newborn death associated with maternal cocaine use.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  122     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-02-27     Completed Date:  1992-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  385-92     Citation Subset:  IM    
School of Dietetics and Human Nutrition, McGill University, Ste. Anne de Bellevue, PQ, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amniotic Fluid / chemistry*
Dietary Carbohydrates / administration & dosage*
Energy Metabolism*
Fructose / administration & dosage
Glucose / administration & dosage,  analysis
Lactates / analysis
Liver Glycogen / analysis
Pregnancy Outcome
Pregnancy, Animal / metabolism*
Rats, Inbred Strains
Regression Analysis
Urea / analysis
Uric Acid / analysis
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Lactates; 0/Liver Glycogen; 30237-26-4/Fructose; 50-99-7/Glucose; 57-13-6/Urea; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Adrenalectomy attenuates the effect of chemical castration on energy balance in rats.
Next Document:  Metabolism of [14C]- and [32P]pyridoxal 5'-phosphate and [3H]pyridoxal administered intravenously to...