| Amniotic fluid collagenase inhibitor: correlation with gestational age and fetal lung maturity. | |
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MedLine Citation:
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PMID: 3004216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Concentrations of collagenase inhibitor in amniotic fluid correlated with gestational age and with indices of fetal lung maturity such as the lecithin/sphingomyelin ratio and the presence of phosphatidylglycerol. Possible sources of amniotic fluid collagenase inhibitor were sought, and a number of tissues and fluids, both maternal and fetal in origin, were found to contain or synthesize this glycoprotein in significant quantities. The highest concentrations were achieved in cultures of lung fibroblasts implicating the fetal lung as a major source. Although collagenase inhibitor is largely present in a free or available state, its specific role, other than that of a general antiproteinase, has not been determined in amniotic fluid. However, the quantitation of amniotic fluid collagenase inhibitor provides an index of the maturation of the connective tissue of the fetal lung and may reflect the ability of the extracellular matrix to meet neonatal demands. |
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Authors:
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G P Stricklin; M J Gast; H G Welgus |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 154 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1986 Jan |
Date Detail:
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Created Date: 1986-02-26 Completed Date: 1986-02-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 134-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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metabolism* Cells, Cultured Chromatography, High Pressure Liquid Enzyme-Linked Immunosorbent Assay Female Fetal Organ Maturity Gestational Age Humans Lung / embryology*, metabolism Microbial Collagenase / antagonists & inhibitors* Phosphatidylcholines / analysis Phosphatidylglycerols / analysis Pregnancy Sphingomyelins / analysis |
| Grant Support | |
ID/Acronym/Agency:
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AM 01525/AM/NIADDK NIH HHS; AM 35069/AM/NIADDK NIH HHS; AM 35805/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylcholines; 0/Phosphatidylglycerols; 0/Sphingomyelins; EC 3.4.24.3/Microbial Collagenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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