Document Detail

Amniotic fluid cardiac troponin T in pathological pregnancies with evidence of chronic fetal hypoxia.
MedLine Citation:
PMID:  16158475     Owner:  NLM     Status:  MEDLINE    
AIM: To determine if prenatally measured cardiac troponin T in the amniotic fluid (Am-TnT) could be used as a marker of fetal myocardial hypoxia and necrosis in pathological pregnancy characterized by increased concentration of amniotic fluid erythropoietin (Am-EPO) as a sign of chronic fetal hypoxia. METHOD: We measured Am-TnT and Am-EPO in 29 pathological and 5 uncomplicated pregnancies. Samples of amniotic fluid were collected prospectively during elective amniocentesis (n=15), cesarean sections (n=17), and before elective induction of labor in two pregnancies with stillbirth. Am-TnT and Am-EPO were determined by chemiluminescent immunological method. RESULTS: Am-TnT was undetectable in normal pregnancies, but it was detectable in 9 of 29 amniotic fluid samples from pathological pregnancies, with a median value of 0.030 microg/L (range, 0.010-111.6 microg/L). Am-EPO values were above normal values (>11 U/L) in all pathological pregnancies. Am-EPO concentration showed positive correlation with the Am-TnT concentration (r=0.526, P=0.003). Median concentration of Am-EPO in 9 pregnancies with detectable Am-TnT was 198 U/L (range, 16-3,378 U/L). In 20 pathologic pregnancies with undetectable Am-TnT, the median concentration of Am-EPO was 39 U/L (range, 12-293 U/L). There was no statistically significant difference between the groups (P=0.051). CONCLUSION: Am-TnT is measurable in some pathological pregnancies with signs of fetal chronic hypoxia and myocardial involvement and could be potentially used as a biochemical marker of fetal myocardial injury.
Vedran Stefanovic; Mikko Loukovaara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Croatian medical journal     Volume:  46     ISSN:  0353-9504     ISO Abbreviation:  Croat. Med. J.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-13     Completed Date:  2005-12-14     Revised Date:  2006-03-14    
Medline Journal Info:
Nlm Unique ID:  9424324     Medline TA:  Croat Med J     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  801-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, 00290 Helsinki, Finland.
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MeSH Terms
Amniotic Fluid / chemistry*
Biological Markers
Cardiomyopathy, Hypertrophic / diagnosis,  pathology*
Case-Control Studies
Chronic Disease
Erythropoietin / analysis*
Fetal Growth Retardation / physiopathology
Fetal Hypoxia / diagnosis,  pathology*
Prospective Studies
Troponin T / analysis*
Reg. No./Substance:
0/Biological Markers; 0/Troponin T; 11096-26-7/Erythropoietin
Comment In:
Croat Med J. 2005 Dec;46(6):999-1000; discussion 1000-1   [PMID:  16342358 ]

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