Document Detail

Amniotic fluid beta-2-microglobulin in normal and complicated pregnancies. Correlation with gestational age, creatinine concentration and L/S ratio.
MedLine Citation:
PMID:  6178654     Owner:  NLM     Status:  MEDLINE    
The beta-2-microglobulin concentrations in 127 aminotic fluid samples, obtained during weeks 32-42 of normal pregnancies (n = 58) and complicated pregnancies (n = 69), were measured and correlated with gestational weeks, amniotic fluid creatinine concentrations and L/S ratios. A significant (p less than 0.001) decrease of beta-2-microglobulin concentration occurred from week 32 to 34 of normal pregnancies, after which the beta-2-microglobulin level was unchanged. There were no significant correlations between beta-2-microglobulin concentrations and amniotic fluid creatinine concentrations of LK/S ratios. The beta-2-microglobulin content was elevated in samples obtained from diabetic and toxemic pregnancies. Measurement of beta-2-microglobulin in amniotic fluid seems to be of limited value for determining fetal age, but it may be useful in estimating fetal renal maturity.
J Puolakka; P Ylöstalo; R Tuimala; J Haapalahti; P A Järvinen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  13     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1982  
Date Detail:
Created Date:  1982-09-10     Completed Date:  1982-09-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / analysis*
Beta-Globulins / analysis*
Creatinine / analysis*
Fetal Organ Maturity
Gestational Age
Kidney / embryology
Phosphatidylcholines / analysis
Pregnancy Complications / metabolism*
Sphingomyelins / analysis
beta 2-Microglobulin / analysis*
Reg. No./Substance:
0/Beta-Globulins; 0/Phosphatidylcholines; 0/Sphingomyelins; 0/beta 2-Microglobulin; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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