Document Detail

Amniotic fluid amino and nucleic acid in normal and neural tube defect pregnancies. A comparison.
MedLine Citation:
PMID:  9987736     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To explore the relationship between fetal amino acids (AAs), which are the components of structural proteins and nucleic acids, and the changes associated with neural tube defects (NTD). STUDY DESIGN: Ten weekly amniotic fluid (AF) samples from normal pregnancies (non-NTD) and 10 from NTD pregnancies between 16 and 20 weeks' gestational age were analyzed for AAs, and the weekly average for the non-NTD and NTD groups was determined. The group mean levels were compared by ANOVA. RESULTS: The weekly group mean levels of methionine, serine and aspartic acid were significantly lower than the weekly group mean levels of the other AAs. The group mean levels of methionine were significantly lower for NTD than for non-NTD pregnancies. CONCLUSION: The mean methionine level in NTD pregnancies was the only AA alteration in NTD. Although the AF levels of the non-NTD pregnancies showed that the levels of serine, aspartic acid and methionine were 3- to 19-fold lower than those of the other AAs, only methionine is essential. Consequently, methionine is rate limiting with respect to the role of structural proteins and nucleic acids in the fetus.
E B Dawson; W A Harris; D R Evans; J W Van Hook
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  44     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-04-29     Completed Date:  1999-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  28-32     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston 77555-0587, USA.
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MeSH Terms
Amino Acids / metabolism*
Amniotic Fluid / metabolism*
Analysis of Variance
Aspartic Acid / metabolism
Case-Control Studies
Fetal Diseases / metabolism*
Gestational Age
Methionine / metabolism
Neural Tube Defects / metabolism*
Serine / metabolism
Reg. No./Substance:
0/Amino Acids; 56-45-1/Serine; 56-84-8/Aspartic Acid; 63-68-3/Methionine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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