Document Detail

Amniotic fluid alphafetoprotein measurements in the early prenatal diagnosis of central nervous system disorders.
MedLine Citation:
PMID:  48438     Owner:  NLM     Status:  MEDLINE    
Amniotic fluid alphafetoprotein (AFP) has been measured in 520 pregnancies between 8 and 24 weeks of gestation. The normal range of values has been defined for fortnightly periods between these limits. Grossly elevated AFP concentrations were found in four pregnancies leading to spina bifida and nine pregnancies leading to anencephaly. Slightly elevated AFP concentrations were found in one twin pregnancy and two pregnancies affected by rhesus isoimmunisation. Normal AFP values were observed in 36 amniotic fluids from pregnancies where the outcome was rhesus isoimmunisation, an inborn error of metabolism, a cytogenetic disorder or a birth defect unrelated to the central nervous system. The reliability of amniotic fluid AFP in the early prenatal diagnosis of spina bifida and anencephaly and the possibility of performing assays on samples sent by post from any part of the world are emphasized.
D J Brock; J B Scrimgeour; M M Nelson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical genetics     Volume:  7     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-08-20     Completed Date:  1975-08-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  163-9     Citation Subset:  IM    
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MeSH Terms
Abortion, Spontaneous
Amniotic Fluid / analysis*
Anencephaly / diagnosis
Central Nervous System Diseases / diagnosis*
Fetal Proteins / analysis*
Infant, Newborn
Pregnancy, Multiple
Prenatal Diagnosis
Rh-Hr Blood-Group System
Spinal Dysraphism / diagnosis
Reg. No./Substance:
0/Alpha-Globulins; 0/Fetal Proteins; 0/Isoantibodies; 0/Rh-Hr Blood-Group System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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