| Amniotic fluid alpha-fetoprotein is not a useful biological marker of pregnancy outcome. | |
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MedLine Citation:
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PMID: 10589054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of our study was to determine if the amniotic fluid alpha-fetoprotein (AFP) level could be a useful predictive biochemical marker of pregnancy outcome. Amniotic fluid AFP measurement was prospectively carried out over a three-year period. After excluding factors susceptible to modifying AFP measurements, 587 subjects with gestational age between 14 and 20 weeks were selected to compare the amniotic fluid AFP mean levels depending on the occurrence of an adverse outcome. No significant associations between amniotic fluid AFP level and poor pregnancy outcome, i.e. pre-eclampsia, preterm delivery, premature rupture of fetal membranes, fetal growth retardation and placental abnormalities were observed. The routine measurement of amniotic fluid alpha-fetoprotein during an amniocentesis procedure was not considered useful in predicting pregnancy complications. |
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Authors:
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E Verspyck; S Degré; M F Hellot; G Descargues; C Philippe; G Labadie; J Bénichou; J P Lemoine; L Marpeau |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 19 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-01-06 Completed Date: 2000-01-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1031-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Rouen University Hospital, Rouen, France. verspyck@chu-rouen.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniocentesis / standards* Amniotic Fluid / chemistry* Biological Markers / analysis Case-Control Studies Female Humans Predictive Value of Tests Pregnancy Pregnancy Complications / diagnosis* Pregnancy Outcome Pregnancy Trimester, Second Prospective Studies alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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