| Amniotic fluid alpha fetoprotein (AFAFP) and maternal serum alpha fetoprotein (MSAFP) in abdominal pregnancies: correlation with extent and site of placental implantation and clinical implications. | |
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MedLine Citation:
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PMID: 8796780 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypotheses are evaluated that in abdominal pregnancies 1) elevated MSAFP is due to an altered maternal-placental interface, and 2) differences in MSAFP levels may reflect placental location within the peritoneal cavity. A review of 1,193 ectopic pregnancies from 1983-1993 identified three cases of advanced abdominal pregnancy. All three had undergone second trimester genetic amniocentesis for amniotic fluid alpha fetoprotein (AFAFP) and karyotype. The clinical course was reviewed (including presentation and surgical findings). MSAFP was elevated in two of the three cases (3.63 and 4.88 MoM). AFAFP and fetal karyotype were normal in all three cases. Elevated MSAFP values were associated with more extensive visceral implantation, longer surgical operative time, greater blood loss and transfusion requirements. Abdominal pregnancies with elevated MSAFP appear to have more extensive placental involvement of the abdominal viscera; this would, in fact, account for the elevated MSAFP values given the normal AFAFP. |
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Authors:
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J B Shumway; J S Greenspoon; A N Khouzami; L D Platt; K J Blakemore |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of maternal-fetal medicine Volume: 5 ISSN: 1057-0802 ISO Abbreviation: J Matern Fetal Med Publication Date: 1996 May-Jun |
Date Detail:
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Created Date: 1996-10-18 Completed Date: 1996-10-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9211288 Medline TA: J Matern Fetal Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 120-3 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniocentesis Amniotic Fluid / chemistry* Biological Markers / analysis, blood Embryo Implantation Female Gestational Age Humans Incidence Karyotyping Placenta / physiology* Pregnancy Pregnancy, Abdominal / blood, diagnosis*, epidemiology Retrospective Studies alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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