Document Detail


Amniotic fluid prolidase activity and oxidative status in neural tube defects.
MedLine Citation:
PMID:  20516661     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate oxidative stress markers and prolidase activity in the amniotic fluid of fetuses with a neural tube defect (NTD) compared to the amniotic fluid of normal fetuses.
METHODS: Amniotic fluid samples from 36 pregnancies of fetuses with NTD were compared with the amniotic fluid from 36 pregnancies of genetically normal fetuses for analysis of oxidative status and prolidase activity. The control group consisted of fetuses from pregnancies that were diagnosed as high-risk according to a 1st or 2nd trimester aneuploidy screening, but which were later confirmed to have normal results. An automated method was used to measure oxidative status. Prolidase enzyme activity was determined using a photometric method.
RESULTS: Prolidase activity, total oxidant status and oxidative stress index of amniotic fluid from fetuses with NTD were significantly higher compared to controls (p < 0.001, p = 0.003 and p = 0.002, respectively), whereas total antioxidant capacity was significantly lower (p < 0.001).
CONCLUSION: Levels of prolidase activity and oxidative stress are increased in the amniotic fluid of fetuses with NTD. These indicators may serve as diagnostic markers in this disease.
Authors:
Mehmet Vural; Hakan Camuzcuoglu; Harun Toy; Nurten Aksoy
Publication Detail:
Type:  Journal Article     Date:  2010-06-03
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  28     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-09     Completed Date:  2010-12-03     Revised Date:  2011-03-22    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  34-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Affiliation:
Department of Obstetrics and Gynecology, Harran University, Sanliurfa, Turkey. drmvural@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid / enzymology*
Dipeptidases / metabolism*
Female
Fetus / enzymology*
Humans
Neural Tube Defects / enzymology*
Oxidation-Reduction
Pregnancy
Chemical
Reg. No./Substance:
EC 3.4.13.-/Dipeptidases; EC 3.4.13.9/proline dipeptidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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