| Amniotic Fluid Inflammation with Negative Culture and Outcome After Cervical Cerclage. | |
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MedLine Citation:
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PMID: 22372938 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective: To determine whether amniotic fluid inflammation, in the absence of infection, is associated with adverse pregnancy outcomes in non-elective cervical cerclage patients. Methods: A retrospective case-control study. The patient population included 82 singleton pregnancies with negative amniotic fluid (AF) cultures. The variables used to define AF inflammation were white blood cell count (WBC) >50 cell/mm(3), glucose <14 mg/dl or interleukin-6 (IL-6) >11.3 ng/ml. The study group consisted of cases with intra-amniotic inflammation. Sub-analysis was performed for the groups in which IL-6 concentrations were measured. Adverse outcomes were evaluated with variables such as gestational age at delivery, interval from cerclage to delivery, chorioamnionitis, and cumulative neonatal morbidity. Results: Elevated AF WBC was correlated with severe and extreme preterm delivery (P<0.05). Decreased AF glucose was associated with histological chorioamnionitis and a decreased cerclage to delivery interval (P<0.05). Elevated AF IL-6 correlated significantly with decreased gestational age at delivery (p<0.012) and decreased cerclage to delivery interval (p<0.001). Elevated IL-6 concentrations associated with severe, extreme preterm delivery (p<0.001) and neonatal death (P<0.001). Conclusion: Elevated AF IL-6, elevated WBC and low amniotic fluid glucose, in the absence of a positive AF culture, are significantly associated with adverse pregnancy outcomes in patients undergoing non-elective cerclage. |
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Authors:
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Eduardo Aguin; Tina Aguin; Marcos Cordoba; Victor Aguin; Robyn Roberts; Samet Albayrak; Michael Kruger; Ray Bahado-Singh |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-28 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, United States, 48201. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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