Document Detail

Amniotic Fluid Inflammation with Negative Culture and Outcome After Cervical Cerclage.
MedLine Citation:
PMID:  22372938     Owner:  NLM     Status:  Publisher    
Abstract Objective: To determine whether amniotic fluid inflammation, in the absence of infection, is associated with adverse pregnancy outcomes in non-elective cervical cerclage patients. Methods: A retrospective case-control study. The patient population included 82 singleton pregnancies with negative amniotic fluid (AF) cultures. The variables used to define AF inflammation were white blood cell count (WBC) >50 cell/mm(3), glucose <14 mg/dl or interleukin-6 (IL-6) >11.3 ng/ml. The study group consisted of cases with intra-amniotic inflammation. Sub-analysis was performed for the groups in which IL-6 concentrations were measured. Adverse outcomes were evaluated with variables such as gestational age at delivery, interval from cerclage to delivery, chorioamnionitis, and cumulative neonatal morbidity. Results: Elevated AF WBC was correlated with severe and extreme preterm delivery (P<0.05). Decreased AF glucose was associated with histological chorioamnionitis and a decreased cerclage to delivery interval (P<0.05). Elevated AF IL-6 correlated significantly with decreased gestational age at delivery (p<0.012) and decreased cerclage to delivery interval (p<0.001). Elevated IL-6 concentrations associated with severe, extreme preterm delivery (p<0.001) and neonatal death (P<0.001). Conclusion: Elevated AF IL-6, elevated WBC and low amniotic fluid glucose, in the absence of a positive AF culture, are significantly associated with adverse pregnancy outcomes in patients undergoing non-elective cerclage.
Eduardo Aguin; Tina Aguin; Marcos Cordoba; Victor Aguin; Robyn Roberts; Samet Albayrak; Michael Kruger; Ray Bahado-Singh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-28
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, United States, 48201.
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