Document Detail

Amniopatch as a treatment for rupture of membranes following laser surgery for twin-twin transfusion syndrome.
MedLine Citation:
PMID:  20090293     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The risk of iatrogenic rupture of membranes (IROM) is 5-30% after operative fetoscopy. The aim of this study was to describe outcomes of patients with IROM following selective laser photocoagulation of communicating vessels (SLPCV) for twin-twin transfusion syndrome (TTTS) who were subsequently treated with amniopatch therapy. METHODS: A review of patients who underwent treatment for mid-trimester TTTS between March 2006 and February 2008 with IROM within 7 days of SLPCV was performed. IROM patients without evidence of preterm labor or chorioamnionitis were offered expectant management, pregnancy termination, or amniopatch therapy. RESULTS: Ninety-three patients were treated with SLPCV, of which three (3.2%) had IROM within 7 days. All three opted for amniopatch therapy which was performed at 18 2/7, 23 1/7, and 22 6/7 weeks' gestation in patients 1, 2 and 3, respectively. In patients 1 and 2, amniopatch therapy sealed membranes within 7 days. A second amniopatch was required for patient 3 before IROM resolved. Gestational ages at delivery were 38 2/7, 37 5/7 and 30 2/7 weeks, respectively. CONCLUSION: Amniopatch is a viable treatment option for iatrogenic ROM following SLPCV.
Bhuvan Pathak; Amer Khan; Samer A Assaf; David A Miller; Ramen H Chmait
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-01-13
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  27     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  134-7     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
University of Southern California, Keck School of Medicine, Maternal Fetal Medicine, Los Angeles, Calif., USA.
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MeSH Terms
Fetal Membranes, Premature Rupture / etiology,  therapy*
Fetofetal Transfusion / surgery*
Fetoscopy / adverse effects
Iatrogenic Disease
Laser Coagulation / adverse effects*
Postoperative Complications / etiology,  therapy*
Pregnancy Outcome
Pregnancy Trimester, Second
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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