| Amnion-derived cellular cytokine solution (ACCS) promotes migration of keratinocytes and fibroblasts. | |
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MedLine Citation:
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PMID: 20395817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amnion-derived Multipotent Progenitor cells appear to be useful as adjuvants in wound healing. Amnion-derived multipotent progenitor cells secrete a unique combination of cytokines and growth factors, known as amnion-derived cellular cytokine solution (ACCS). In the skin, a cytokine communication network between mesenchymal and epithelial cells tightly controls keratinocyte and fibroblast migration, proliferation and differentiation-key determinants of wound healing. To evaluate the influence of ACCS on the migratory behavior of keratinocytes and fibroblasts, cell migration was assayed quantitatively using a Boyden chamber. Chemotactic migration activity of fibroblasts or keratinocytes through the membrane determined the influence of ACCS. In the presence of ACCS, fibroblasts and keratinocytes demonstrated a statistically significant (P < 0.05) increase in migration when compared with controls. These cell types, critical to normal wound healing, may be influenced to accelerate migration in wounds, thus accelerating wound repair/healing. |
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Authors:
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M Georgina Uberti; Yvonne N Pierpont; Francis Ko; Terry E Wright; Charlotte A Smith; C Wayne Cruse; Martin C Robson; Wyatt G Payne |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of plastic surgery Volume: 64 ISSN: 1536-3708 ISO Abbreviation: Ann Plast Surg Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805336 Medline TA: Ann Plast Surg Country: United States |
Other Details:
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Languages: eng Pagination: 632-5 Citation Subset: IM |
Affiliation:
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Institute for Tissue Regeneration, Repair, and Rehabilitation, Bay Pines VA Healthcare System, Bay Pines, FL, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amnion
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cytology* Cell Movement / drug effects* Cells, Cultured Cytokines / pharmacology* Fibroblasts / cytology* Humans Keratinocytes / cytology* Polycarboxylate Cement Solutions Tissue Scaffolds |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Polycarboxylate Cement; 0/Solutions; 25766-59-0/polycarbonate |
| Comments/Corrections | |
Erratum In:
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Ann Plast Surg. 2010 Jul;65(1):116 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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