Document Detail

Ammonium and sodium urates precipitating from synthetic urine and fine structure of urate renal calculi.
MedLine Citation:
PMID:  10424396     Owner:  NLM     Status:  MEDLINE    
A study of ammonium and sodium urate precipitation in vitro and the fine structure of several urate renal calculi was carried out to contribute to an understanding of the participation of ammonium and sodium urates in urolithiasis. Ammonium urate precipitated in vitro in two different morphologies: a typical spherulite morphology formed at high supersaturation and disorganized needle-like crystals formed at low supersaturation. In all cases sodium urate precipitated in vitro as bundles of curved fibrils, its crystallization being inhibited by calcium in concentrations between 20 and 60 mg/l depending on the sodium urate supersaturation. From a collection of 1300 renal calculi, only three had ammonium urate as their main component (0.2%), three were mixed calculi (0.2%) consisting of ammonium urate and calcium oxalate (two) or uric acid (one), and in one calculus ammonium urate was present as a minor component. Only in a mixed calculus of uric acid and calcium oxalate was sodium urate detected in a very low quantity. The study of the fine structure of the renal calculi constituted mainly by ammonium urate demonstrated similar patterns in which spherulites, needle-like individual crystals and an amorphous mass of ammonium urate with abundant organic matter in non-organized structures coexist. As minor components, struvite or calcium oxalate crystals were found. A general mechanism of the formation of such calculi is proposed.
F Grases; A I Villacampa; A Costa-Bauzá
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Urological research     Volume:  27     ISSN:  0300-5623     ISO Abbreviation:  Urol. Res.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-09-08     Completed Date:  1999-09-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0364311     Medline TA:  Urol Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Laboratory of Urolithiasis Research, Faculty of Sciences, University of Balearic Islands, Palma de Mallorca, Spain.
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MeSH Terms
Chemical Precipitation
Crystallography, X-Ray
Hydrogen-Ion Concentration
Kidney Calculi / urine*
Microscopy, Electron, Scanning
Quaternary Ammonium Compounds / chemistry*,  urine
Sodium Compounds / chemistry*,  urine
Uric Acid / chemistry*,  urine
Reg. No./Substance:
0/Quaternary Ammonium Compounds; 0/Sodium Compounds; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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