| Ammonium ion and the anaerobic threshold in man. | |
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MedLine Citation:
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PMID: 2019178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine if ammonium ion plays a role in the lactate and ventilatory thresholds of incremental exercise, we investigated the effects on blood lactate and ventilation of NH(4+)-buffering by monosodium glutamate. Six normal volunteers underwent intravenous loading with MSG, 9 g, in a randomized, double-blind, saline placebo controlled crossover study. Four of the six subjects had a greater than 10 percent fall in peak (NH4+) following MSG (37 +/- 2.0 vs 25 +/- 4.3 micrograms/dl p = 0.003, PLB vs MSG). When MSG blunted the rise in venous (NH4+) during exercise, uncoupling of the LT and VT was observed. Specifically, with suppression of peak exercise (NH4+) by MSG, the LT was delayed (r = -0.84, p = 0.03), the VT was earlier (r = 0.86, p = 0.02), and the VO2 difference between the LT and VT widened (r = -0.90, p = 0.02). We conclude that NH4+ plays a role in determining the LT and VT of incremental exercise and that the VT may not be exclusively dependent on blood lactate. |
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Authors:
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D M Systrom; C V Fragoso; D J Kanarek; H Kazemi |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Chest Volume: 99 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-05-30 Completed Date: 1991-05-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1197-202 Citation Subset: AIM; IM |
Affiliation:
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Pulmonary and Critical Care Unit (Medical Services), Massachusetts General Hospital, Harvard Medical School, Boston 02114. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ammonia
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blood* Anaerobic Threshold / physiology* Double-Blind Method Exercise / physiology Humans Lactates / blood Lactic Acid Sodium Glutamate / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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HL 29493/HL/NHLBI NIH HHS; HL07354/HL/NHLBI NIH HHS; MO 1RR01066-11S2/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 142-47-2/Sodium Glutamate; 50-21-5/Lactic Acid; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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