Document Detail

Ammonium ion and the anaerobic threshold in man.
MedLine Citation:
PMID:  2019178     Owner:  NLM     Status:  MEDLINE    
To determine if ammonium ion plays a role in the lactate and ventilatory thresholds of incremental exercise, we investigated the effects on blood lactate and ventilation of NH(4+)-buffering by monosodium glutamate. Six normal volunteers underwent intravenous loading with MSG, 9 g, in a randomized, double-blind, saline placebo controlled crossover study. Four of the six subjects had a greater than 10 percent fall in peak (NH4+) following MSG (37 +/- 2.0 vs 25 +/- 4.3 micrograms/dl p = 0.003, PLB vs MSG). When MSG blunted the rise in venous (NH4+) during exercise, uncoupling of the LT and VT was observed. Specifically, with suppression of peak exercise (NH4+) by MSG, the LT was delayed (r = -0.84, p = 0.03), the VT was earlier (r = 0.86, p = 0.02), and the VO2 difference between the LT and VT widened (r = -0.90, p = 0.02). We conclude that NH4+ plays a role in determining the LT and VT of incremental exercise and that the VT may not be exclusively dependent on blood lactate.
D M Systrom; C V Fragoso; D J Kanarek; H Kazemi
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  99     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-05-30     Completed Date:  1991-05-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1197-202     Citation Subset:  AIM; IM    
Pulmonary and Critical Care Unit (Medical Services), Massachusetts General Hospital, Harvard Medical School, Boston 02114.
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MeSH Terms
Ammonia / blood*
Anaerobic Threshold / physiology*
Double-Blind Method
Exercise / physiology
Lactates / blood
Lactic Acid
Sodium Glutamate / diagnostic use
Grant Support
Reg. No./Substance:
0/Lactates; 142-47-2/Sodium Glutamate; 50-21-5/Lactic Acid; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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