Document Detail

Ammonium acid urate calculi: a reevaluation of risk factors.
MedLine Citation:
PMID:  10022703     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We reevaluate the demographic and metabolic risk factors for ammonium acid urate stones. MATERIALS AND METHODS: Since 1986, 23 women and 21 men ranging in age from 20 to 81 years (mean 48.7) were treated for stones partly composed of ammonium acid urate. Stone composition ranged from 2 to 60% ammonium acid urate (mean 24.1) of the total stone mass. No patient had a pure ammonium acid urate stone, although 11 (25%) had stones with ammonium acid urate as the predominant crystal. RESULTS: In the 44 patients 1 or more potential risk factors for ammonium acid urate were identified. Of the patients 11 (25%) had a history of inflammatory bowel disease with 10 (22.7%) having undergone ileostomy diversion, 6 (13.6%) admitted to a history of significant laxative use or abuse, 18 (40.9%) were morbidly obese, 16 (36.4%) had a history of recurrent urinary tract infections and 9 (20.5%) had a history of recurrent uric acid stones. CONCLUSIONS: Patients clearly at risk for stones with an ammonium acid urate component include those with a history of inflammatory bowel disease and ileostomy diversion or laxative abuse. Other factors that may potentially enhance ammonium acid urate stone formation include morbid obesity, recurrent uric acid calculi and recurrent urinary tract infection. A careful history followed by further metabolic evaluation is warranted in these patients.
J J Soble; B D Hamilton; S B Streem
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  161     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-03-11     Completed Date:  1999-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  869-73     Citation Subset:  AIM; IM    
Department of Urology, Cleveland Clinic Foundation, Ohio 44195, USA.
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MeSH Terms
Aged, 80 and over
Middle Aged
Risk Factors
Uric Acid / analysis*
Urinary Calculi / chemistry*
Reg. No./Substance:
69-93-2/Uric Acid

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