Document Detail

Ammonia transport in the mammalian kidney.
MedLine Citation:
PMID:  3885755     Owner:  NLM     Status:  MEDLINE    
Ammonia, an important urinary buffer in mammals, is synthesized primarily in the proximal tubules and is transferred to the final urine by a sequence of specialized transport processes. The pathway of ammonia transfer to the urine involves secretion into the proximal tubules, absorption from the loops of Henle, accumulation in the renal medullary interstitium, and secretion into the collecting ducts. Ammonia is transported as NH3 at some nephron sites and as NH+4 at others. In this paper, we discuss the physical basis of NH3 and NH+4 transport in epithelia and then describe ammonia transport mechanisms in individual nephron segments. Information about ammonia transport in individual nephron segments from isolated perfused tubule studies is integrated with data from in vivo studies to obtain an expanded overall model of renal ammonia handling.
D W Good; M A Knepper
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of physiology     Volume:  248     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-05-14     Completed Date:  1985-05-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  F459-71     Citation Subset:  IM    
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MeSH Terms
Acids / metabolism
Ammonia / metabolism*
Biological Transport
Cell Membrane / metabolism
Kidney / metabolism*
Kidney Cortex / metabolism
Kidney Medulla / metabolism
Kidney Tubules, Collecting / metabolism
Kidney Tubules, Distal / metabolism
Kidney Tubules, Proximal / metabolism
Loop of Henle / metabolism
Mammals / metabolism*
Nephrons / metabolism
Reg. No./Substance:
0/Acids; 0/Ions; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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