| Ammonia elimination as a rapid index of viability in liver grafts in dogs. | |
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MedLine Citation:
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PMID: 1987436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined intraoperative changes in blood ammonia levels and the correlation with graft viability in orthotopic liver transplantation (OLTx) in 29 dogs. Blood ammonia levels following total hepatectomy were examined using five dogs. These levels immediately following hepatectomy (15 min) were significantly higher (212 +/- 29 micrograms/dl) over values noted before hepatectomy (93 +/- 11 micrograms/dl, P less than 0.05). OLTx was performed using the cuff technique. The animals were divided into two groups: Group A (n = 6 pairs), OLTx with a nonpreserved fresh graft; Group B (n = 6 pairs), OLTx with an 8-hr preserved graft with lactated Ringer (4 degrees C). In both groups, the blood ammonia levels before the surgery and at the anhepatic phase data did not differ; however, following reperfusion, the levels in Group B were significantly higher (211 +/- 26 at 15 min, 200 +/- 50 micrograms/dl at 30 min) than those in Group A (121 +/- 10 at 15 min; P less than 0.01, 109 +/- 9 micrograms/dl at 30 min; P less than 0.05). The blood ammonia level highly correlated with adenosine triphosphate contents in the liver tissue, blood level of lactic acid, and amount of bile output, all pertinent indicators of the graft viability. Thus, the potential to eliminate ammonia immediately after reperfusion can serve as an indicator of graft viability. The intraoperative monitoring of blood ammonia levels can be included in management guidelines in cases of liver transplantation. |
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Authors:
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K Fukuzawa; M Shimada; H Itasaka; K Takenaka; K Sugimachi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of surgical research Volume: 50 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-02-21 Completed Date: 1991-02-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 88-92 Citation Subset: IM |
Affiliation:
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Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Alanine Transaminase / blood Ammonia / blood* Animals Aspartate Aminotransferases / blood Bile / metabolism Dogs Graft Survival* Hepatectomy Intraoperative Period L-Lactate Dehydrogenase / blood Liver / metabolism Liver Transplantation* |
| Chemical | |
Reg. No./Substance:
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56-65-5/Adenosine Triphosphate; 7664-41-7/Ammonia; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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