Document Detail


Amlodipine reduces graft coronary artery disease in rat heterotopic cardiac allografts.
MedLine Citation:
PMID:  8312305     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The long-acting dihydropyridine calcium antagonist, amlodipine, suppresses atherogenesis in experimental animals. To determine the effect of amlodipine on allograft coronary artery disease in the transplanted heart, we used a working heterotopic rat heart transplant model. All rats were immunosuppressed with cyclosporine as a single agent and randomized to a control group (n = 9) and an amlodipine-treated group (n = 9). After 90 days, rats were killed, and the extent of graft coronary artery disease was assessed by digitizing morphometry. No significant differences were noted for mean arterial blood pressure or serum total cholesterol, high-density lipoprotein cholesterol, or triglycerides at the time of death. Amlodipine was associated with significantly less narrowing in the coronary arteries (mean percent narrowing for control group, 48.9% +/- 8.2%; mean percent narrowing for amlodipine group, 25.5% +/- 9.9%; P < 0.05). These findings suggest a role for calcium channel blockers in the prevention of graft coronary artery disease.
Authors:
J B Atkinson; J H Wudel; S J Hoff; J R Stewart; W H Frist
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  12     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:    1993 Nov-Dec
Date Detail:
Created Date:  1994-03-23     Completed Date:  1994-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1036-43     Citation Subset:  IM    
Affiliation:
Department of Pathology, Vanderbilt University, Nashville, TN 37232.
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MeSH Terms
Descriptor/Qualifier:
Amlodipine / pharmacology*
Animals
Coronary Disease / etiology,  pathology,  prevention & control*
Coronary Vessels / pathology
Heart Transplantation / adverse effects*
Lipids / blood
Random Allocation
Rats
Rats, Inbred BN
Rats, Inbred Lew
Transplantation, Heterotopic*
Chemical
Reg. No./Substance:
0/Lipids; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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