Document Detail

Amlodipine lowers blood pressure without increasing sympathetic activity or activating the renin-angiotensin system in patients with essential hypertension.
MedLine Citation:
PMID:  9476031     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Recent clinical studies suggest that the reflex increase in sympathetic nervous activity accompanying a reduction in blood pressure may contribute to the untoward effects of dihydropyridine calcium antagonists. The aim of this study was to examine whether plasma noradrenaline levels and renin activity are increased with the reduction of blood pressure during the initial phase of administration of the long-acting dihydropyridine calcium antagonist amlodipine. METHODS: The effects of amlodipine on ambulatory blood pressure and on diurnal variations in plasma noradrenaline and renin activity were examined 1, 4, and 7 days after the start of amlodipine administration in eight inpatients with essential hypertension. RESULTS: The 24-h mean systolic and diastolic blood pressure on day 7 was significantly lower than it was 1 day before the start of treatment. There was no change in the mean heart rate. The mean trough to peak ratios of systolic and diastolic blood pressure of seven patients were 61% and 71%, respectively. Diurnal patterns of plasma noradrenaline levels and renin activity 1, 4, and 7 days after the start of amlodipine administration were unchanged. CONCLUSION: The antihypertensive effects of amlodipine were of slow onset and long duration and were not accompanied by an increase in sympathetic activity or activation of the renin-angiotensin system.
M Sasaguri; N Matsumoto; K Noda; M Koga; A Kinoshita; M Ideishi; K Arakawa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  53     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1997  
Date Detail:
Created Date:  1998-03-19     Completed Date:  1998-03-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  197-201     Citation Subset:  IM    
Department of Internal Medicine, Fukuoka University, School of Medicine, Japan.
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MeSH Terms
Amlodipine / pharmacology*,  therapeutic use
Blood Pressure / drug effects*
Calcium Channel Blockers / pharmacology*
Hypertension / drug therapy*,  physiopathology
Middle Aged
Norepinephrine / blood
Renin / blood
Renin-Angiotensin System / drug effects*
Sympathetic Nervous System / drug effects*
Reg. No./Substance:
0/Calcium Channel Blockers; 51-41-2/Norepinephrine; 88150-42-9/Amlodipine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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