| Amlodipine in patients with stable angina pectoris treated with beta-blockers. Double-blind comparison with placebo. | |
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MedLine Citation:
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PMID: 9536505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to assess additional anti-ischaemic effects of amlodipine (AML) on coronary artery disease (CAD) treated with beta-blockers, 32 patients with CAD, verified on angiograms, and stable angina were randomized to receive 5 mg/day of AML or placebo, increasing to 10 mg/day after 2 weeks. Baseline recording of 24-h ambulatory ECG and blood pressure, echocardiography and bicycle exercise test was repeated after treatment for 2 weeks and for 6 weeks. Reduction of ambulatory ischaemia was not significantly greater with AML than with placebo. In exercise tests the time to 0.1 mV ST segment depression and the total exercise time remained unaltered. Blood pressure was reduced by 10 mg AML. The total variability and the very low frequency component of heart rate were reduced after both doses. The clinical significance of the possible unfavourable change in autonomic modulation of the heart in CAD patients is not known. |
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Authors:
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J Rossinen; J Partanen; M S Nieminen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 32 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 1998 |
Date Detail:
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Created Date: 1998-05-19 Completed Date: 1998-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: NORWAY |
Other Details:
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Languages: eng Pagination: 41-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Helsinki University Central Hospital, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use* Amlodipine / administration & dosage, therapeutic use* Angina Pectoris / diagnosis, drug therapy*, physiopathology Blood Pressure / drug effects Blood Pressure Monitoring, Ambulatory Coronary Angiography Dose-Response Relationship, Drug Double-Blind Method Echocardiography, Doppler, Pulsed Electrocardiography, Ambulatory / drug effects Exercise Test Female Follow-Up Studies Heart Rate / drug effects Humans Male Middle Aged Vasodilator Agents / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Vasodilator Agents; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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