Document Detail


Amlodipine in patients with stable angina pectoris treated with beta-blockers. Double-blind comparison with placebo.
MedLine Citation:
PMID:  9536505     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to assess additional anti-ischaemic effects of amlodipine (AML) on coronary artery disease (CAD) treated with beta-blockers, 32 patients with CAD, verified on angiograms, and stable angina were randomized to receive 5 mg/day of AML or placebo, increasing to 10 mg/day after 2 weeks. Baseline recording of 24-h ambulatory ECG and blood pressure, echocardiography and bicycle exercise test was repeated after treatment for 2 weeks and for 6 weeks. Reduction of ambulatory ischaemia was not significantly greater with AML than with placebo. In exercise tests the time to 0.1 mV ST segment depression and the total exercise time remained unaltered. Blood pressure was reduced by 10 mg AML. The total variability and the very low frequency component of heart rate were reduced after both doses. The clinical significance of the possible unfavourable change in autonomic modulation of the heart in CAD patients is not known.
Authors:
J Rossinen; J Partanen; M S Nieminen
Related Documents :
6488225 - Diastolic time during exercise in normal subjects and in patients with coronary artery ...
7297145 - Effect of platelet suppressant treatment with dipyridamole and aspirin on exercise perf...
2220535 - Clinical significance of plasminogen activator inhibitor activity in patients with exer...
11780565 - Kallikrein-kinin system activation and its interactions with other plasma haemostatic c...
10416555 - Effects of short-term strenuous endurance exercise upon corpus luteum function.
2107165 - Plasma [h+] regulation and whole blood [co2] in exercising ponies.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  32     ISSN:  1401-7431     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  1998  
Date Detail:
Created Date:  1998-05-19     Completed Date:  1998-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  41-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Helsinki University Central Hospital, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use*
Amlodipine / administration & dosage,  therapeutic use*
Angina Pectoris / diagnosis,  drug therapy*,  physiopathology
Blood Pressure / drug effects
Blood Pressure Monitoring, Ambulatory
Coronary Angiography
Dose-Response Relationship, Drug
Double-Blind Method
Echocardiography, Doppler, Pulsed
Electrocardiography, Ambulatory / drug effects
Exercise Test
Female
Follow-Up Studies
Heart Rate / drug effects
Humans
Male
Middle Aged
Vasodilator Agents / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Vasodilator Agents; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Treatment of infected median sternotomy wounds with a myocutaneous latissimus dorsi muscle flap.
Next Document:  Conservative treatment of a paracardial abscess following post-infarct patch grafting.