Document Detail

Amlodipine in patients with stable angina pectoris treated with beta-blockers. Double-blind comparison with placebo.
MedLine Citation:
PMID:  9536505     Owner:  NLM     Status:  MEDLINE    
In order to assess additional anti-ischaemic effects of amlodipine (AML) on coronary artery disease (CAD) treated with beta-blockers, 32 patients with CAD, verified on angiograms, and stable angina were randomized to receive 5 mg/day of AML or placebo, increasing to 10 mg/day after 2 weeks. Baseline recording of 24-h ambulatory ECG and blood pressure, echocardiography and bicycle exercise test was repeated after treatment for 2 weeks and for 6 weeks. Reduction of ambulatory ischaemia was not significantly greater with AML than with placebo. In exercise tests the time to 0.1 mV ST segment depression and the total exercise time remained unaltered. Blood pressure was reduced by 10 mg AML. The total variability and the very low frequency component of heart rate were reduced after both doses. The clinical significance of the possible unfavourable change in autonomic modulation of the heart in CAD patients is not known.
J Rossinen; J Partanen; M S Nieminen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  32     ISSN:  1401-7431     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  1998  
Date Detail:
Created Date:  1998-05-19     Completed Date:  1998-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  41-8     Citation Subset:  IM    
Department of Medicine, Helsinki University Central Hospital, Finland.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Amlodipine / administration & dosage,  therapeutic use*
Angina Pectoris / diagnosis,  drug therapy*,  physiopathology
Blood Pressure / drug effects
Blood Pressure Monitoring, Ambulatory
Coronary Angiography
Dose-Response Relationship, Drug
Double-Blind Method
Echocardiography, Doppler, Pulsed
Electrocardiography, Ambulatory / drug effects
Exercise Test
Follow-Up Studies
Heart Rate / drug effects
Middle Aged
Vasodilator Agents / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Vasodilator Agents; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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