Document Detail


Amlodipine compared to nitrendipine for the treatment of mild-to-moderate hypertension.
MedLine Citation:
PMID:  1839437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study compared the efficacy and safety of 8 weeks of open treatment with the dihydropyridine calcium antagonists amlodipine and nitrendipine in mild-to-moderate hypertension. Interim analysis of data from 74 patients (43 male, 31 female) showed that amlodipine normalized diastolic blood pressure (less than or equal to 90 mmHg) in 95% of patients compared with 83% of nitrendipine-treated patients. Nitrendipine produced a statistically significant increase in heart rate at 2 and 4 weeks of therapy but there was no significant change in heart rate in amlodipine-treated patients. Amlodipine-treated patients reported fewer adverse events (26%) than did the nitrendipine-treated group (47%), with two patients from the nitrendipine group discontinuing treatment due to treatment-related adverse events. Adverse events in the amlodipine-treated group were mild to moderate. The incidence of flushing was higher in nitrendipine-treated patients (25%) than in amlodipine-treated patients (10%). This relative difference in the incidence of vasodilator-related side effects is probably explained by the gradual onset of effect with amlodipine.
Authors:
R Englert; P Beressem; E von Manteuffel; M Stafunsky; M Kramar
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  67 Suppl 5     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1991  
Date Detail:
Created Date:  1992-04-28     Completed Date:  1992-04-28     Revised Date:  2009-10-22    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S35-7     Citation Subset:  IM    
Affiliation:
Veitlipp 2, Gars am Inn, Germany.
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MeSH Terms
Descriptor/Qualifier:
Amlodipine
Calcium Channel Blockers / therapeutic use*
Female
Heart Rate / drug effects
Humans
Hypertension / drug therapy*
Male
Middle Aged
Nifedipine / analogs & derivatives*,  therapeutic use
Nitrendipine / therapeutic use*
Vasodilation / drug effects
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 39562-70-4/Nitrendipine; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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