| Amlodipine compared to nitrendipine for the treatment of mild-to-moderate hypertension. | |
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MedLine Citation:
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PMID: 1839437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study compared the efficacy and safety of 8 weeks of open treatment with the dihydropyridine calcium antagonists amlodipine and nitrendipine in mild-to-moderate hypertension. Interim analysis of data from 74 patients (43 male, 31 female) showed that amlodipine normalized diastolic blood pressure (less than or equal to 90 mmHg) in 95% of patients compared with 83% of nitrendipine-treated patients. Nitrendipine produced a statistically significant increase in heart rate at 2 and 4 weeks of therapy but there was no significant change in heart rate in amlodipine-treated patients. Amlodipine-treated patients reported fewer adverse events (26%) than did the nitrendipine-treated group (47%), with two patients from the nitrendipine group discontinuing treatment due to treatment-related adverse events. Adverse events in the amlodipine-treated group were mild to moderate. The incidence of flushing was higher in nitrendipine-treated patients (25%) than in amlodipine-treated patients (10%). This relative difference in the incidence of vasodilator-related side effects is probably explained by the gradual onset of effect with amlodipine. |
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Authors:
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R Englert; P Beressem; E von Manteuffel; M Stafunsky; M Kramar |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Postgraduate medical journal Volume: 67 Suppl 5 ISSN: 0032-5473 ISO Abbreviation: Postgrad Med J Publication Date: 1991 |
Date Detail:
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Created Date: 1992-04-28 Completed Date: 1992-04-28 Revised Date: 2009-10-22 |
Medline Journal Info:
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Nlm Unique ID: 0234135 Medline TA: Postgrad Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S35-7 Citation Subset: IM |
Affiliation:
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Veitlipp 2, Gars am Inn, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amlodipine Calcium Channel Blockers / therapeutic use* Female Heart Rate / drug effects Humans Hypertension / drug therapy* Male Middle Aged Nifedipine / analogs & derivatives*, therapeutic use Nitrendipine / therapeutic use* Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 39562-70-4/Nitrendipine; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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