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Amlodipine Increases Vitamin D Levels More Than Valsartan in Newly Diagnosed Hypertensive Patients: Pointing to an Additional Effect on Bone Metabolism or a Novel Marker of Inflammation?
MedLine Citation:
PMID:  23560469     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hypertension is a major challenge for public health. Appropriate antihypertensive treatment seem to provide a better life with lower morbidity and mortality rates. Another pathologic condition, osteoporosis, mainly affects postmenouposal women, and constitutes a growing body of risks after a particular age. As bone is a dynamic organ system that is directly related to calcium and phosphor metabolism, imbalance in these two parameters upon aging or menopause finally may lead to osteoporosis. Today, both osteoporosis and high blood pressure are major morbidities, especially in the elderly population. There are some intriguing results on the effects of antihypertensive agents on bone metabolism in the literature. In this study, we aimed to investigate the effects of widely used antihypertensive agents, valsartan and amlodipine on vitamin D levels in newly diagnosed hypertensive population. We found that amlodipine increased vitamin D levels significantly in patients with a newly diagnosed hypertension on a 12-week treatment duration compared to valsartan.
Authors:
Seyit Ahmet Ay; Murat Karaman; Mustafa Cakar; Sevket Balta; Erol Arslan; Fatih Bulucu; Seref Demirbas; Turgay Celik; Mehmet Ilkin Naharci; Sait Demirkol; Omer Kurt; Ergun Bozoglu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-8
Journal Detail:
Title:  Renal failure     Volume:  -     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Internal Medicine, Gulhane Medical Academy, School of Medicine , Etlik-Ankara , Turkey ;
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