| Amitriptyline poisoning in a 2-year old. | |
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MedLine Citation:
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PMID: 16430415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a case of a 2-year-old boy who ingested 35 mg.kg(-1) of amitriptyline. He developed central nervous system toxicity, as demonstrated by coma and seizures and cardiac toxicity (cardiac arrest) within 1 h of ingestion. The cardiac toxicity was refractory to standard therapy. His cardiac rhythm alternated between ventricular tachycardia and pulseless ventricular tachycardia/ventricular fibrillation for a period of 17 h. Following prolonged cardiopulmonary resuscitation and aggressive supportive management, the patient recovered both cardiovascularly and neurologically. An echocardiogram and MRI brain were subsequently performed and were normal. The patient was discharged 2 weeks later with normal cognitive, behavioral and motor function. We discuss the benefit of prolonged and effective cardiopulmonary resuscitation in the management of this potentially fatal poisoning. |
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Authors:
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Catherine Deegan; Kay O'Brien |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Paediatric anaesthesia Volume: 16 ISSN: 1155-5645 ISO Abbreviation: Paediatr Anaesth Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-24 Completed Date: 2006-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206575 Medline TA: Paediatr Anaesth Country: France |
Other Details:
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Languages: eng Pagination: 174-7 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia and Intensive Care Medicine, Children's University Hospital, Temple Street, Dublin 1, Ireland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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administration & dosage Amitriptyline / poisoning* Analgesics, Non-Narcotic / poisoning* Anticonvulsants / administration & dosage Blood Gas Analysis / methods Cardiopulmonary Resuscitation / methods* Child, Preschool Coma / chemically induced Heart Arrest / chemically induced, therapy Humans Hypnotics and Sedatives / administration & dosage Kidney / drug effects, metabolism Magnesium Sulfate / administration & dosage Male Overdose / drug therapy Seizures / chemically induced, drug therapy Sodium Bicarbonate / administration & dosage Time Factors Treatment Outcome Vasodilator Agents / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Analgesics, Non-Narcotic; 0/Anticonvulsants; 0/Hypnotics and Sedatives; 0/Vasodilator Agents; 144-55-8/Sodium Bicarbonate; 50-48-6/Amitriptyline; 7487-88-9/Magnesium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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