| Amisulpride-induced acute akathisia in OCD: an example of dysfunctional dopamine-serotonin interactions? | |
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MedLine Citation:
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PMID: 21746752 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We report about a clinical observation in a well-characterized group of patients with obsessive-compulsive disorder (OCD) during an experimental medicine study in which a single dose of amisulpride (a selective D(2/3 )antagonist) was administered. Almost half of the OCD patients, in particular those with less severe obsessive-compulsive symptoms, experienced acute akathisia in response to the amisulpride challenge. This unexpectedly high incidence of akathisia in the selective serotonin reuptake inhibitor (SSRI)-treated patients with OCD suggests that individual differences in dopamine-serotonin interactions underlie the clinical heterogeneity of OCD, and may thus explain the insufficiency of SSRI monotherapy in those patients not experiencing a satisfactory outcome in symptom reduction. We further speculate about the neuropathology possibly underlying this clinical observation and outline a testable hypothesis for future molecular imaging studies. |
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Authors:
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Karen D Ersche; Paul Cumming; Kevin J Craig; Ulrich Müller; Naomi A Fineberg; Edward T Bullmore; Trevor W Robbins |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-11 |
Journal Detail:
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Title: Journal of psychopharmacology (Oxford, England) Volume: - ISSN: 1461-7285 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907828 Medline TA: J Psychopharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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