Document Detail


Amisulpride-induced acute akathisia in OCD: an example of dysfunctional dopamine-serotonin interactions?
MedLine Citation:
PMID:  21746752     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report about a clinical observation in a well-characterized group of patients with obsessive-compulsive disorder (OCD) during an experimental medicine study in which a single dose of amisulpride (a selective D₂/₃ antagonist) was administered. Almost half of the OCD patients, in particular those with less severe obsessive-compulsive symptoms, experienced acute akathisia in response to the amisulpride challenge. This unexpectedly high incidence of akathisia in the selective serotonin reuptake inhibitor (SSRI)-treated patients with OCD suggests that individual differences in dopamine-serotonin interactions underlie the clinical heterogeneity of OCD, and may thus explain the insufficiency of SSRI monotherapy in those patients not experiencing a satisfactory outcome in symptom reduction. We further speculate about the neuropathology possibly underlying this clinical observation and outline a testable hypothesis for future molecular imaging studies.
Authors:
Karen D Ersche; Paul Cumming; Kevin J Craig; Ulrich Müller; Naomi A Fineberg; Edward T Bullmore; Trevor W Robbins
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-07-11
Journal Detail:
Title:  Journal of psychopharmacology (Oxford, England)     Volume:  26     ISSN:  1461-7285     ISO Abbreviation:  J. Psychopharmacol. (Oxford)     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2013-01-15     Revised Date:  2014-08-28    
Medline Journal Info:
Nlm Unique ID:  8907828     Medline TA:  J Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  887-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Akathisia, Drug-Induced / etiology*,  metabolism
Dopamine / metabolism*
Female
Humans
Male
Obsessive-Compulsive Disorder / drug therapy*,  metabolism
Serotonin / metabolism*
Serotonin Uptake Inhibitors / therapeutic use
Sulpiride / administration & dosage,  adverse effects,  analogs & derivatives*
Grant Support
ID/Acronym/Agency:
093875//Wellcome Trust; G0701497//Medical Research Council
Chemical
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 333DO1RDJY/Serotonin; 7MNE9M8287/Sulpiride; AA0G3TW31W/sultopride; VTD58H1Z2X/Dopamine
Comments/Corrections

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